埃塞俄比亚北部提格雷州阿伊德综合专科医院员工中糖尿病前期及相关可改变心血管危险因素的患病率

Prevalence of Prediabetes and Related Modifiable Cardiovascular Risk Factors Among Employees of Ayder Comprehensive Specialized Hospital, Tigray, Northern Ethiopia.

作者信息

Gidey Gebrekidan, Hiruy Mulugeta, Teklu Desalegn, Ramanathan Kumaresan, Amare Hagos

机构信息

Ayder Comprehensive Specialized Hospital, College of Health Sciences, Mekelle, Ethiopia.

School of Medicine, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

出版信息

Diabetes Metab Syndr Obes. 2023 Mar 8;16:643-652. doi: 10.2147/DMSO.S307823. eCollection 2023.

DOI:10.2147/DMSO.S307823

PMID:36919104

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10008371/

Abstract

BACKGROUND

Prediabetes is considered an important risk factor for type 2 diabetes and related cardiovascular problems. However, evidence shows that both prediabetes and its associated cardiovascular risk factors could be mitigated through lifestyle modification. This study aims at determining the magnitude of prediabetes and related modifiable cardiovascular risk factors as an initial step towards undertaking such mitigation measures.

METHODS

A cross-sectional study was conducted on employees of a tertiary care hospital from March to June/2019. Socio-demographic data were collected using a self-administered questionnaire. Anthropometric and blood pressure measurements were performed following WHO guidelines. Biochemical parameters were assayed following standard operating procedures. Categorical variables are summarized using frequencies and percentages. Normality test was performed ahead of describing the numeric data and log transformations were carried out when appropriate. International Diabetes Federation (IDF) and American Diabetes Association (ADA) criteria were used to classify glycemic status. Likewise, IDF and revised National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) were employed for the diagnosis of metabolic syndrome.

RESULTS

In this study, we engaged a total of 265 employees. About 35.1% were males and 64.9% were females. The median age was 29 (9) years. About 5.7% and 18.1% had prediabetes based on IDF and ADA criteria, respectively. Equally, 3.4% had FBS levels that meet the criteria for overt diabetes on IDF and ADA. Besides, 55.1% had a metabolic risk as implied by the elevated waist-to-height ratio (WhtR), 24.2% had hypertriglyceridemia, 27.9% had above optimal LDL and 57% had low HDL. Overall, 17.9% and 21.9% of the participants had metabolic syndrome according to IDF and revised NCEP ATP III criteria, respectively.

CONCLUSION

The prevalence of prediabetes and metabolic syndrome observed in hospital employees is comparable with the general population.

摘要

背景

糖尿病前期被认为是2型糖尿病及相关心血管问题的重要危险因素。然而，有证据表明，通过生活方式的改变，糖尿病前期及其相关的心血管危险因素都可以得到缓解。本研究旨在确定糖尿病前期及相关可改变心血管危险因素的程度，作为采取此类缓解措施的第一步。

方法

2019年3月至6月对一家三级护理医院的员工进行了横断面研究。使用自填问卷收集社会人口学数据。按照世界卫生组织指南进行人体测量和血压测量。按照标准操作程序测定生化参数。分类变量用频率和百分比进行汇总。在描述数值数据之前进行正态性检验，并在适当的时候进行对数转换。采用国际糖尿病联盟（IDF）和美国糖尿病协会（ADA）标准对血糖状态进行分类。同样，采用IDF和修订后的美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP ATP III）诊断代谢综合征。

结果

本研究共纳入265名员工。男性约占35.1%，女性约占64.9%。中位年龄为29（9）岁。根据IDF和ADA标准，分别约有5.7%和18.1%的人患有糖尿病前期。同样，3.4%的人空腹血糖水平符合IDF和ADA关于显性糖尿病的标准。此外，55.1%的人腰高比（WhtR）升高意味着存在代谢风险，24.2%的人患有高甘油三酯血症，27.9%的人低密度脂蛋白水平高于最佳值，57%的人高密度脂蛋白水平低。总体而言，根据IDF和修订后的NCEP ATP III标准，分别有17.9%和21.9%的参与者患有代谢综合征。