Kang Hongmei, Chen Lamei, Li Qin, Chen Huan, Zhang Liangke
Chongqing Research Center for Pharmaceutical Engineering, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, College of Pharmacy, Chongqing Medical University, No. 1, Yixueyuan Road, Yuzhong District, Chongqing 400016, China.
ACS Appl Mater Interfaces. 2023 Mar 29;15(12):15129-15139. doi: 10.1021/acsami.2c22578. Epub 2023 Mar 14.
Due to the complexity of tumor pathogenesis and the heterogeneity of the tumor microenvironment (TME), it is difficult to obtain satisfactory efficacy with a single therapy. In this study, a hyaluronic acid (HA)-modified ruthenium nanoaggregate (RuNA) and glucose oxidase (GOD) -loaded manganese dioxide (MnO) nanoflowers (MRG@HA) have been prepared. RuNA and MnO nanoflowers can generate O in TME, alleviating tumor tissue hypoxia. RuNA is a good photothermal agent for high-temperature ablation of solid tumors under infrared laser irradiation. GOD consumes glucose in the presence of O and converts it into glucuronic acid and hydrogen peroxide, reducing tumor nutrient supply while promoting Fenton-like reactions of MnO nanoflowers and RuNA to produce cytotoxic hydroxyl radicals. MRG@HA can also actively target tumor cells through the affinity of HA and CD44 receptor to improve the antitumor effect. and studies have confirmed the synergistic effect of MRG@HA with tumor photothermal/chemodynamic/starvation therapy, showing its great potential for clinical application in tumor therapy.
由于肿瘤发病机制的复杂性和肿瘤微环境（TME）的异质性，单一疗法难以获得令人满意的疗效。在本研究中，制备了一种透明质酸（HA）修饰的钌纳米聚集体（RuNA）和负载葡萄糖氧化酶（GOD）的二氧化锰（MnO）纳米花（MRG@HA）。RuNA和MnO纳米花可在TME中产生O，缓解肿瘤组织缺氧。RuNA是一种良好的光热剂，可在红外激光照射下对实体瘤进行高温消融。GOD在有O的情况下消耗葡萄糖并将其转化为葡萄糖醛酸和过氧化氢，减少肿瘤营养供应，同时促进MnO纳米花和RuNA的类芬顿反应以产生细胞毒性羟基自由基。MRG@HA还可通过HA与CD44受体的亲和力主动靶向肿瘤细胞，以提高抗肿瘤效果。 和 研究证实了MRG@HA与肿瘤光热/化学动力学/饥饿疗法的协同作用，显示出其在肿瘤治疗临床应用中的巨大潜力。
