Department of Pathology, Center of Life Sciences, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
HMS Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Cancer Res. 2023 Mar 15;83(6):809-813. doi: 10.1158/0008-5472.CAN-22-3014.
Circular RNAs (circRNA) are a recently described class of RNA molecules that have attracted substantial attention as new components of disease mechanisms and as potential biomarkers in multiple diseases, including cancer. CircRNAs are often highly conserved and exhibit developmental stage- and disease-specific expression. Several studies have reported circRNA expression patterns that are associated with specific cancer types and with patient prognosis. Here, we overview the active registered clinical trials that investigate the value of circRNAs as cancer biomarkers and discuss the potential of circRNAs in clinical cancer care. Taken together, circRNAs are actively being investigated as diagnostic, predictive, and prognostic biomarkers, and their potential to serve as therapeutic intervention points motivates ongoing translational and clinical research.
环状 RNA（circRNA）是一类最近被描述的 RNA 分子，作为疾病机制的新组成部分以及包括癌症在内的多种疾病的潜在生物标志物，引起了广泛关注。circRNA 通常高度保守，并表现出发育阶段和疾病特异性表达。一些研究报告了与特定癌症类型和患者预后相关的 circRNA 表达模式。在这里，我们综述了正在进行的临床试验，这些试验旨在研究 circRNAs 作为癌症生物标志物的价值，并讨论了 circRNAs 在临床癌症治疗中的潜力。总之，circRNAs 正在被积极研究作为诊断、预测和预后生物标志物，其作为治疗干预点的潜力激发了正在进行的转化和临床研究。
