ST133 型产铁载体广泛耐药肠杆菌的表型和基因组特征。
Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei.
机构信息
Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
China Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology, Zhejiang Agricultural and Forestry University, Hangzhou, China.
出版信息
Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0173722. doi: 10.1128/aac.01737-22. Epub 2023 Mar 15.
We identified an ST133 extensively drug-resistant Enterobacter hormaechei, C210017, with increased virulence in the Galleria mellonella infection model. Genomic analysis suggested it carried antibiotic resistance genes and , and genes and encoding the virulence factor, siderophores. Comparative genomics of C210017 and the 178 ST133 strains in the database suggested they all belonged to serotype O3 and most strains (77.5%) carried the IncHI2 superplasmids associated with the resistance, virulence, and adaptation of the host strain.
我们鉴定出一株具有广泛耐药性的肠杆菌属霍氏亚种 ST133，C210017，在金龟子幼虫感染模型中具有增强的毒力。基因组分析表明，它携带抗生素耐药基因 和 ，以及编码毒力因子的基因 和 ，铁载体。C210017 与数据库中 178 株 ST133 菌株的比较基因组学表明，它们都属于血清型 O3，大多数菌株（77.5%）携带与耐药性、毒力和宿主菌株适应性相关的 IncHI2 超质粒。
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