棘白菌素耐药的耳念珠菌在鼠类胃肠道中出现是由于突变。
Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to Mutations.
机构信息
Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
出版信息
Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0124322. doi: 10.1128/aac.01243-22. Epub 2023 Mar 15.
Abstract
Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant ; however, the MICs of isolates with mutation in R1354 remained below the micafungin breakpoint .
摘要
耳念珠菌对多种抗真菌药物具有耐药性。本研究调查了其抗真菌敏感性，并探索了用棘白菌素治疗肠道定植野生型耳念珠菌的小鼠分离株中的突变。分离出具有突变的耐药性耳念珠菌，包括 S639F、S639Y、D642Y、R1354H 或 R1354Y，这些突变被鉴定为米卡芬净和卡泊芬净耐药；然而，具有 R1354 突变的分离株的 MIC 值仍低于米卡芬净的折点。
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