Center for Arctic Health and Molecular Epidemiology, Department of Public Health, Aarhus University, Denmark.
Center for Arctic Health and Molecular Epidemiology, Department of Public Health, Aarhus University, Denmark; Greenland Center for Health Research, University of Greenland, Nuuk, Greenland.
Sci Total Environ. 2020 Jan 1;698:134118. doi: 10.1016/j.scitotenv.2019.134118. Epub 2019 Aug 27.
The Greenlandic population has some of the highest levels of environmental persistent organic pollutants (POPs) globally. Studies have previously found POPs to be linked with disturbance of child development, immune function and reproductive abilities. We investigated the associations between serum POP levels of pregnant women in Greenland and their infant's birth weight, length, head circumference and gestational age (GA) at birth. Pregnant Greenlandic women (n = 504) were enrolled during pregnancy and serum levels of the lipophilic POPs (Organochlorine pesticides, Polychlorinated biphenyls and Polybrominated diphenyl ethers) and the amphiphilic POPs, Perfluoroalkylated substances (PFASs), were measured. We analysed the associations between maternal serum levels of POPs and birth weight, length, head circumference and GA using linear regression analysis. We found significant inverse associations between Perfluorooctanoic Acid (PFOA) and birth weight (adjusted β = -119 g, 95% CI: -201; -36), birth length (adjusted β = -0.37 cm, 95% CI: -0.76; 0.02, borderline significant) and head circumference (adjusted β = -0.35 cm, 95% CI: -0.59; -0.10) and a positive association with GA (adjusted β = 0.45 week, 95% CI: 0.17; 0.74). For the lipophilic POPs, we found an overall trend of inverse associations to foetal growth indices. In conclusion, we found that the amphiphilic PFOA had a significant inversely association with foetal growth indices, whereas GA was positively associated. The data indicate that POPs have a negative effect on foetal growth.
格陵兰岛居民血液中的持久性有机污染物（POPs）水平位居世界前列。此前的研究发现，POPs 与儿童发育、免疫功能和生殖能力受损有关。本研究旨在探讨格陵兰岛孕妇血清中 POP 水平与婴儿出生体重、身长、头围和胎龄（GA）之间的关系。研究纳入了 504 名格陵兰岛孕妇，在妊娠期间采集其血清样本，检测脂溶性 POP（有机氯农药、多氯联苯和多溴联苯醚）和具有两亲性的 POP（全氟烷基物质，PFAS）的水平。我们采用线性回归分析来评估母体血清中 POP 水平与出生体重、身长、头围和 GA 之间的关系。结果显示，全氟辛酸（PFOA）与出生体重（校正后 β=-119g，95%CI：-201；-36）、出生身长（校正后 β=-0.37cm，95%CI：-0.76；0.02，边界显著）和头围（校正后 β=-0.35cm，95%CI：-0.59；-0.10）呈显著负相关，与 GA 呈正相关（校正后 β=0.45 周，95%CI：0.17；0.74）。对于脂溶性 POP，我们发现其与胎儿生长指标总体呈负相关趋势。综上，本研究表明，具有两亲性的 PFOA 与胎儿生长指标呈显著负相关，而 GA 呈正相关。这些数据表明 POP 对胎儿生长有负面影响。
