Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
Department of Anatomy, Comenius University in Bratislava, Martin, Slovakia.
Eur J Pharmacol. 2023 Jun 15;949:175655. doi: 10.1016/j.ejphar.2023.175655. Epub 2023 Mar 13.
Metabolic reprogramming of cancer cells is a common hallmark of malignant transformation. The preference for aerobic glycolysis over oxidative phosphorylation in tumors is a well-studied phenomenon known as the Warburg effect. Importantly, metabolic transformation of cancer cells also involves alterations in signaling cascades contributing to lipid metabolism, amino acid flux and synthesis, and utilization of ketone bodies. Also, redox regulation interacts with metabolic reprogramming during malignant transformation. Flavonoids, widely distributed phytochemicals in plants, exert various beneficial effects on human health through modulating molecular cascades altered in the pathological cancer phenotype. Recent evidence has identified numerous flavonoids as modulators of critical components of cancer metabolism and associated pathways interacting with metabolic cascades such as redox balance. Flavonoids affect lipid metabolism by regulating fatty acid synthase, redox balance by modulating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activity, or amino acid flux and synthesis by phosphoglycerate mutase 1. Here, we discuss recent preclinical evidence evaluating the impact of flavonoids on cancer metabolism, focusing on lipid and amino acid metabolic cascades, redox balance, and ketone bodies.
癌细胞的代谢重编程是恶性转化的共同标志。肿瘤中有氧糖酵解对氧化磷酸化的偏好是一种被广泛研究的现象，称为沃伯格效应。重要的是，癌细胞的代谢转化还涉及到脂质代谢、氨基酸通量和合成以及酮体利用的信号级联改变。此外，氧化还原调控在恶性转化过程中与代谢重编程相互作用。类黄酮是植物中广泛分布的植物化学物质，通过调节病理癌症表型中改变的分子级联，对人类健康发挥各种有益作用。最近的证据已经确定了许多类黄酮作为癌症代谢和相关途径的关键成分的调节剂，这些途径与氧化还原平衡等代谢级联相互作用。类黄酮通过调节脂肪酸合酶来影响脂质代谢，通过调节核因子-红细胞因子 2 相关因子 2（Nrf2）活性来调节氧化还原平衡，或通过磷酸甘油酸变位酶 1 来调节氨基酸通量和合成。在这里，我们讨论了最近的临床前证据，评估了类黄酮对癌症代谢的影响，重点是脂质和氨基酸代谢级联、氧化还原平衡和酮体。
