Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.
Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Nutrients. 2023 Aug 22;15(17):3675. doi: 10.3390/nu15173675.
Worldwide, the demand for natural and synthetic sweeteners in the food industry as an alternative to refined sugar is increasing. This has prompted more research to be conducted to estimate its safety and effects on health. The gut microbiome is critical in metabolizing selected sweeteners which might affect overall health. Recently, more studies have evaluated the relationship between sweeteners and the gut microbiome. This review summarizes the current knowledge regarding the role played by the gut microbiome in metabolizing selected sweeteners. It also addresses the influence of the five selected sweeteners and their metabolites on GI cancer-related pathways. Overall, the observed positive effects of sweetener consumption on GI cancer pathways, such as apoptosis and cell cycle arrest, require further investigation in order to understand the underlying mechanism.
在全球范围内，食品工业对天然和合成甜味剂的需求正在增加，以替代精制糖。这促使人们进行更多的研究来评估其安全性和对健康的影响。肠道微生物群在代谢某些甜味剂方面起着关键作用，这些甜味剂可能会影响整体健康。最近，更多的研究评估了甜味剂与肠道微生物群之间的关系。这篇综述总结了目前关于肠道微生物群在代谢某些甜味剂方面所起作用的知识。它还讨论了五种选定的甜味剂及其代谢物对胃肠道癌症相关途径的影响。总的来说，观察到甜味剂消费对胃肠道癌症途径的积极影响，如细胞凋亡和细胞周期停滞，需要进一步研究以了解其潜在机制。
