Department of Otolaryngology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Front Immunol. 2023 Jul 21;14:1224443. doi: 10.3389/fimmu.2023.1224443. eCollection 2023.
Tumor-associated macrophages (TAMs) are significant immunocytes infiltrating the tumor microenvironment(TME). Recent research has shown that TAMs exhibit diversity in terms of their phenotype, function, time, and spatial distribution, which allows for further classification of TAM subtypes. The metabolic efficiency of fatty acid oxidation (FAO) varies among TAM subtypes. FAO is closely linked to the production of reactive oxygen species (ROS), which play a role in processes such as oxidative stress. Current evidence demonstrates that FAO and ROS can influence TAMs' recruitment, polarization, and phagocytosis ability either individually or in combination, thereby impacting tumor progression. But the specific mechanisms associated with these relationships still require further investigation. We will review the current status of research on the relationship between TAMs and tumor development from three aspects: ROS and TAMs, FAO and TAMs, and the interconnectedness of FAO, ROS, and TAMs.
肿瘤相关巨噬细胞（TAMs）是浸润肿瘤微环境（TME）的重要免疫细胞。最近的研究表明，TAMs 在表型、功能、时间和空间分布上表现出多样性，这使得 TAM 亚型能够进一步分类。脂肪酸氧化（FAO）的代谢效率在 TAM 亚型之间有所不同。FAO 与活性氧（ROS）的产生密切相关，ROS 在氧化应激等过程中发挥作用。目前的证据表明，FAO 和 ROS 可以单独或联合影响 TAMs 的募集、极化和吞噬能力，从而影响肿瘤的进展。但是，与这些关系相关的具体机制仍需要进一步研究。我们将从三个方面综述 TAMs 与肿瘤发生发展关系的研究现状：ROS 与 TAMs、FAO 与 TAMs 以及 FAO、ROS 和 TAMs 的相互关系。
