Cognitive Neuroscience Program, Department of Psychology, Florida International University, Miami, Florida 33199, USA.
Clinical Science Program, Department of Psychology, Florida International University, Miami, Florida 33199, USA.
Learn Mem. 2023 Mar 15;30(3):55-62. doi: 10.1101/lm.053628.122. Print 2023 Mar.
The hippocampal formation (HF) facilitates declarative memory, with subfields providing unique contributions to memory performance. Maturational differences across subfields facilitate a shift toward increased memory specificity, with peripuberty sitting at the inflection point. Peripuberty is also a sensitive period in the development of anxiety disorders. We believe HF development during puberty is critical to negative overgeneralization, a common feature of anxiety disorders. To investigate this claim, we examined the relationship between mnemonic generalization and a cross-sectional pubertal maturity index (PMI) derived from partial least squares correlation (PLSC) analyses of subfield volumes and structural connectivity from T1-weighted and diffusion-weighted scans, respectively. Participants aged 9-14 yr, from clinical and community sources, performed a recognition task with emotionally valent (positive, negative, and neutral) images. HF volumetric PMI was positively associated with generalization for negative images. Hippocampal-medial prefrontal cortex connectivity PMI evidenced a behavioral relationship similar to that of the HF volumetric approach. These findings reflect a novel developmentally related balance between generalization behavior supported by the hippocampus and its connections with other regions, with maturational differences in this balance potentially contributing to negative overgeneralization during peripuberty.
海马结构（HF）有助于陈述性记忆，其各个亚区对记忆表现有独特的贡献。亚区的成熟差异有助于记忆特异性的增加，青春期是转折点。青春期也是焦虑障碍发展的敏感时期。我们认为青春期 HF 的发育对于负面过度泛化至关重要，这是焦虑障碍的一个常见特征。为了验证这一说法，我们研究了记忆泛化与基于部分最小二乘相关分析（PLSC）的横截面青春期成熟指数（PMI）之间的关系，该指数来自于亚区体积和结构连接的 T1 加权和弥散加权扫描。来自临床和社区来源的 9-14 岁参与者进行了一项带有情感效价（积极、消极和中性）的图像识别任务。HF 体积 PMI 与负面图像的泛化呈正相关。海马-内侧前额叶皮层连接 PMI 表现出与 HF 体积方法相似的行为关系。这些发现反映了海马支持的泛化行为与其他区域的连接之间一种新颖的与发育相关的平衡，这种平衡的成熟差异可能导致青春期期间的负面过度泛化。
