Vanderhasselt Marie-Anne, Sanchez-Lopez Alvaro, Pulopulos Matias, Razza Lais B, De Smet Stefanie, Brunoni André Russowsky, Baeken Chris, De Raedt Rudi, Allaert Jens
Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Ghent Experimental Psychiatry (GHEP) lab, Ghent, Belgium.
Int J Clin Health Psychol. 2023 Oct-Dec;23(4):100384. doi: 10.1016/j.ijchp.2023.100384. Epub 2023 Mar 5.
The prefrontal cortex plays a crucial role in cognitive processes, both during anticipatory and reactive modes of cognitive control. Transcranial Direct Current Stimulation (tDCS) can modulate these cognitive resources. However, there is a lack of research exploring the impact of tDCS on emotional material processing in the prefrontal cortex, particularly in regard to proactive and reactive modes of cognitive control. In this study, 35 healthy volunteers underwent both real and sham tDCS applied to the right prefrontal cortex in a counterbalanced order, and then completed the Cued Emotion Control Task (CECT). Pupil dilation, a measure of cognitive resource allocation, and behavioral outcomes, such as reaction time and accuracy, were collected. The results indicate that, as compared to sham stimulation, active right-sided tDCS reduced performance and resource allocation in both proactive and reactive modes of cognitive control. These findings highlight the importance of further research on the effects of tDCS applied to the right prefrontal cortex on cognitive engagement, particularly for clinical trials utilizing the present electrode montage in combination with cognitive interventions.
前额叶皮质在认知过程中起着至关重要的作用，无论是在认知控制的预期模式还是反应模式下。经颅直流电刺激（tDCS）可以调节这些认知资源。然而，缺乏研究探索tDCS对前额叶皮质情绪材料加工的影响，特别是在认知控制的主动和反应模式方面。在本研究中，35名健康志愿者以平衡顺序接受了施加于右侧前额叶皮质的真实和伪tDCS，然后完成了线索情绪控制任务（CECT）。收集了瞳孔扩张（一种认知资源分配的指标）以及反应时间和准确性等行为结果。结果表明，与伪刺激相比，右侧主动tDCS在认知控制的主动和反应模式下均降低了表现和资源分配。这些发现凸显了进一步研究tDCS应用于右侧前额叶皮质对认知参与的影响的重要性，特别是对于使用当前电极设置并结合认知干预的临床试验而言。
