Department of Medical Psychology, Air Force Medical University, Xi'an, China.
Department of Nursing, Air Force Medical University, Xi'an, China.
Brain Res. 2022 Jan 1;1774:147722. doi: 10.1016/j.brainres.2021.147722. Epub 2021 Nov 11.
Transcranial direct current stimulation (tDCS) has received considerable attention as a new option to facilitate cognitive ability or rehabilitation in healthy populations or in individuals with neuropsychiatric disorders. However, the tDCS effect varies widely, possibly because individual differences in initial performance have frequently been ignored in previous research. Here, we aimed to examine the influence of initial performance on inhibitory control after tDCS. Fifty-six participants were randomly divided into three groups: anodal, cathodal and sham stimulation. The go/no-go task, stop-signal task and Stroop task were performed to measure inhibitory control before and immediately after tDCS. tDCS was applied to the F4 site (international 10-20 system), corresponding to the right dorsolateral prefrontal cortex (rDLPFC), for 20 min with an intensity of 1.5 mA. Neither anodal nor cathodal stimulation had significant effects on the performance of these three tasks at the group level in comparison with sham stimulation. However, the analyses at the individual level only showed a negative relationship between baseline performance and the magnitude of change in go/no-go task performance following cathodal tDCS, indicating the dependence of the change amount on initial performance, with greater gains (or losses) observed in individuals with poorer (or better) initial performance. Together, the initial performance modulates the proactive inhibitory effect of cathodal tDCS of the rDLPFC. Additionally, the rDLPFC plays a crucial role in proactive inhibition.
经颅直流电刺激（tDCS）作为一种新的选择，在促进健康人群或神经精神障碍患者的认知能力或康复方面受到了相当多的关注。然而，tDCS 的效果差异很大，这可能是因为以前的研究经常忽略了个体初始表现的差异。在这里，我们旨在研究初始表现对 tDCS 后抑制控制的影响。56 名参与者被随机分为三组：阳极、阴极和假刺激。在 tDCS 之前和之后立即进行 Go/No-Go 任务、停止信号任务和 Stroop 任务，以测量抑制控制。tDCS 应用于 F4 部位（国际 10-20 系统），对应于右背外侧前额叶皮层（rDLPFC），强度为 1.5 mA，持续 20 分钟。与假刺激相比，阳极或阴极刺激在组水平上均未对这三个任务的表现产生显著影响。然而，个体水平的分析仅表明阴极 tDCS 后 Go/No-Go 任务表现的基线表现与变化幅度之间存在负相关，表明变化量取决于初始表现，初始表现较差（或较好）的个体观察到更大的收益（或损失）。总之，初始表现调节了 rDLPFC 阴极 tDCS 的主动抑制作用。此外，rDLPFC 在主动抑制中起着至关重要的作用。
