Department of Dermatology, Ichinomiya Municipal Hospital, Ichinomiya, Japan.
Department of Pathology, Ichinomiya Municipal Hospital, Ichinomiya, Japan.
Nagoya J Med Sci. 2023 Feb;85(1):123-126. doi: 10.18999/nagjms.85.1.123.
Blockade of the secretion of immunoglobulins leads to their accumulation in plasma cells, resulting in condensed immunoglobulins in the rough endoplasmic reticulum of plasma cells, termed Russell bodies. They are sometimes found in lymphoplasmacellular inflammation of the intestinal mucosa and in lymphoid cell malignancies, but only very rarely in skin diseases. Here, we report an 86-year-old female who presented with a lesion with the prominent accumulation of Russell bodies underlying pseudocarcinomatous hyperplasia with fungal infection in the face. Immunohistochemical staining showed the cells containing Russell bodies to be positive for CD138 and the Russell bodies to be positive for immunoglobulin κ and λ light chains. The present case suggests that when inflammatory cell infiltration with abundant round intracellular eosinophilic materials is observed in the dermis, the dermal accumulation of Russell bodies should be considered in cases with reactive pseudocarcinomatous hyperplasia with fungal infection.
封闭免疫球蛋白的分泌会导致其在浆细胞中蓄积，从而使浆细胞的粗面内质网中出现浓缩的免疫球蛋白，被称为 Russell 小体。它们有时可见于肠黏膜的淋巴浆细胞炎症和淋巴样细胞恶性肿瘤中，但在皮肤病中非常罕见。在此，我们报告了一例 86 岁女性病例，其面部存在真菌感染伴假癌性增生的病变，伴有 Russell 小体的明显蓄积。免疫组化染色显示含有 Russell 小体的细胞 CD138 阳性，Russell 小体免疫球蛋白 κ 和 λ 轻链阳性。本病例提示，当真皮内存在大量圆形细胞内嗜酸性物质的炎症细胞浸润时，对于真菌感染伴反应性假癌性增生的病例，应考虑真皮内 Russell 小体蓄积。
