Al-Rawaf Sarah, Alowami Salem, Riddell Robert, Naqvi Asghar
3710McMaster University, Hamilton, Canada.
Mt. Sinai Hospital, Toronto, Canada.
Int J Surg Pathol. 2021 Dec;29(8):877-881. doi: 10.1177/10668969211008251. Epub 2021 Apr 8.
Russell bodies are accumulation of immunoglobulin in plasma cells forming intracytoplasmic inclusions. Russell body colitis is rare with only 3 cases described in the English literature up to date. We report a 78-year-old male with cirrhosis showing prominent cecal infiltration of Russell body containing plasma cells. Plasma cells showed no nuclear atypia or mitoses, and no evidence of light chain restriction. In this article, we report a fourth case of Russell body colitis, that is unique in being localized to the cecum in contrast to the other 3, 1 of which was in an inflammatory polyp in the sigmoid colon, 1 in a rectal tubulovillous adenoma and 1 as part of diffuse gastrointestinal disease. This is therefore the first report of localized Russell body typhlitis, occurring in a cirrhotic patient in whom an adjacent erosion was likely nonsteroidal anti-inflammatory drug-associated, a combination that may have facilitated the formation of Russell bodies.
拉塞尔小体是免疫球蛋白在浆细胞内积聚形成的胞质内包涵体。拉塞尔小体性结肠炎很罕见，截至目前英文文献中仅报道过3例。我们报告1例78岁男性肝硬化患者，其盲肠有大量含拉塞尔小体的浆细胞浸润。浆细胞无核异型性或核分裂象，也没有轻链限制的证据。在本文中，我们报告第4例拉塞尔小体性结肠炎，其独特之处在于病变局限于盲肠，与其他3例不同，其他3例中1例位于乙状结肠炎性息肉内，1例位于直肠管状绒毛状腺瘤内，1例为弥漫性胃肠道疾病的一部分。因此，这是首例局限性拉塞尔小体性盲肠炎，发生于1例肝硬化患者，其相邻糜烂可能与非甾体抗炎药有关，这种情况可能促进了拉塞尔小体的形成。
