Bereda Gudisa
Department of Pharmacy, Negelle Health Science College, Negelle, Oromia Regional State, Ethiopia.
Ann Med Surg (Lond). 2023 Feb 8;85(3):431-434. doi: 10.1097/MS9.0000000000000151. eCollection 2023 Mar.
Coronavirus disease 2019 (COVID-19) aggravates preexisting diabetes mellitus and contributes to newly discovered hypertension by increasing blood pressure by inhibiting the activity of angiotensin-converting enzyme 2 in the rennin-angiotensin system. Diabetes patients may be more vulnerable to COVID-19 due to chronic comorbidities such as obesity and cardiovascular disease such as hypertension.
On 23 March 2022, a retired black African woman in her 60s was taken into the emergency room with the chief complaints of frequent midnight urine, hazy vision, headache, fever, and tingling in her hands and feet. A throat swab PCR test that revealed positive results after 28 h was used to confirm COVID-19. Her electrocardiogram showed sinus tachycardia with a heart rate of 105 beats per minute. Fluid resuscitation (0.9% normal saline) of 1000 ml and drip insulin administration commenced as soon as she was brought to an ICU.
In this case report, the patient had been previously diagnosed with type 2 diabetes mellitus. COVID-19 affects the beta cells, forcing them to release insulin and increasing insulin insufficiency, which leads to her blood glucose raising. Type 2 diabetes mellitus is therefore the most frequent comorbidity of COVID-19 in this case report.
Poor blood glucose management in the case of COVID-19 may increase the pathogen's susceptibility, the likelihood that patients will be admitted to the hospital, and the likelihood that mortality will be enhanced.
2019冠状病毒病(COVID-19)会加重已有的糖尿病,并通过抑制肾素-血管紧张素系统中血管紧张素转换酶2的活性来升高血压,从而导致新发现的高血压。糖尿病患者可能因肥胖和高血压等心血管疾病等慢性合并症而更容易感染COVID-19。
2022年3月23日,一名60多岁的退休非洲裔黑人女性因频繁夜尿、视力模糊、头痛、发热以及手脚刺痛等主要症状被送入急诊室。一项咽喉拭子PCR检测在28小时后显示阳性结果,用于确诊COVID-19。她的心电图显示窦性心动过速,心率为每分钟105次。她一被送往重症监护病房,就开始进行1000毫升的液体复苏(0.9%生理盐水)并静脉滴注胰岛素。
在本病例报告中,患者此前已被诊断为2型糖尿病。COVID-19会影响β细胞,促使它们释放胰岛素并增加胰岛素不足,从而导致她的血糖升高。因此,2型糖尿病是本病例报告中COVID-19最常见的合并症。
COVID-19患者血糖管理不善可能会增加病原体易感性、患者入院可能性以及死亡率增加的可能性。