Bereda Gudisa
Pharmacy Department, All Africa Leprosy, Tuberculosis and Rehabilitation Training Centre, Zenebework, Kolfe Keranio, Addis Ababa, Ethiopia.
Ann Med Surg (Lond). 2023 Apr 18;85(5):2208-2211. doi: 10.1097/MS9.0000000000000635. eCollection 2023 May.
The coronavirus disease of 2019 (COVID-19) infection typically affects the lungs but can also cause life-threatening heart issues. Heart failure is a common condition that can occur either with an existing heart condition or de novo as part of the clinical course of COVID-19.
On 11 October 2022, a 60-year-old middle-aged black African woman widow was admitted with a history of muscular weakness for 2 days, a lack of appetite, and occasional vomiting for 1 day. She arrived at the emergency room after complaining for 2 days of peeing less than usual, a fast heartbeat, swelling in the feet, pink blood-tinged mucus, fever, headache, dehydration, a nonproductive cough, and shortness of breath. The left ventricular ejection fraction was 43% on the echocardiogram. Routine reverse transcription polymerase chain reaction testing was performed in the emergency room; she tested COVID-19 positive. To treat her proven COVID-19 infection, she received subcutaneous enoxaparin 80 mg every 12 h as prophylaxis for deep venous thromboembolism.
A COVID-19 infection can induce cardiac failure and arrhythmias, as well as cause direct harm to the heart. This study explains how enoxaparin has dual benefits in this case report: it reduces the risk of venous thromboembolism in the COVID-19 hospitalized case and prevents death and cardiac ischemia in myocardial infarction.
Higher mortality and more frequent acute decompensation may be caused by the capacity of severe acute respiratory syndrome associated coronavirus 2 to cause myocardial injury, as well as by patients with chronic heart failure's lower baseline features, decreased cardiopulmonary reserve, and susceptibility for myocardial injury.
2019年冠状病毒病(COVID-19)感染通常影响肺部,但也可导致危及生命的心脏问题。心力衰竭是一种常见病症,可在已有心脏疾病的基础上发生,也可作为COVID-19临床病程的一部分新发。
2022年10月11日,一名60岁的非洲黑人中年寡妇因肌肉无力2天、食欲不振和偶尔呕吐1天入院。她在抱怨小便比平时少、心跳加快、脚部肿胀、粉红色带血黏液、发热、头痛、脱水、干咳和呼吸急促2天后抵达急诊室。超声心动图显示左心室射血分数为43%。在急诊室进行了常规逆转录聚合酶链反应检测;她的COVID-19检测呈阳性。为治疗已确诊的COVID-19感染,她每12小时接受80毫克皮下注射依诺肝素,以预防深静脉血栓栓塞。
COVID-19感染可诱发心力衰竭和心律失常,还会对心脏造成直接损害。本研究在该病例报告中解释了依诺肝素如何具有双重益处:它降低了COVID-19住院病例中静脉血栓栓塞的风险,并预防了心肌梗死中的死亡和心脏缺血。
严重急性呼吸综合征相关冠状病毒2导致心肌损伤的能力,以及慢性心力衰竭患者较低的基线特征、心肺储备降低和心肌损伤易感性,可能导致更高的死亡率和更频繁的急性失代偿。