Pestka J J, Lin W S, Miller E R
Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824-1224.
Food Chem Toxicol. 1987 Nov;25(11):855-8. doi: 10.1016/0278-6915(87)90264-x.
The emetic activity of 15-acetyldeoxynivalenol (15-ADON), a deoxynivalenol (DON) precursor, was evaluated in swine over a dose range of 25-200 micrograms/kg body weight and found to be very similar to that of DON. The minimum effective oral doses for 15-ADON and DON were 75 and 50 micrograms/kg, respectively, with 3/15 of the 15-ADON- and 4/15 of the DON-treated pigs exhibiting emesis, over the total dose range. The minimum effective ip doses for 15-ADON and DON were also 75 and 50 micrograms/kg, respectively, with 9/15 pigs in each group exhibiting emesis, over the total dose range. For pigs receiving 15-ADON and DON ip, increased dosage was associated with decreased average time to vomition, increased duration of emesis and increased average number of vomitions.
脱氧雪腐镰刀菌烯醇（DON）的前体15 - 乙酰脱氧雪腐镰刀菌烯醇（15 - ADON）的催吐活性在体重25 - 200微克/千克剂量范围内的猪身上进行了评估，发现其与DON非常相似。15 - ADON和DON的最小有效口服剂量分别为75和50微克/千克，在整个剂量范围内，15 - ADON处理组的15头猪中有3头、DON处理组的15头猪中有4头出现呕吐。15 - ADON和DON的最小有效腹腔注射剂量也分别为75和50微克/千克，在整个剂量范围内，每组15头猪中有9头出现呕吐。对于腹腔注射15 - ADON和DON的猪，剂量增加与平均呕吐时间缩短、呕吐持续时间延长和平均呕吐次数增加有关。
