Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-957 Olsztyn, Poland.
Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego Str. 13, 10-718 Olsztyn, Poland.
Toxins (Basel). 2020 Jul 19;12(7):461. doi: 10.3390/toxins12070461.
Mycotoxins are secondary metabolites produced by various fungal species. They are commonly found in a wide range of agricultural products. Mycotoxins contained in food enter living organisms and may have harmful effects on many internal organs and systems. The gastrointestinal tract, which first comes into contact with mycotoxins present in food, is particularly vulnerable to the harmful effects of these toxins. One of the lesser-known aspects of the impact of mycotoxins on the gastrointestinal tract is the influence of these substances on gastrointestinal innervation. Therefore, the present study is the first review of current knowledge concerning the influence of mycotoxins on the enteric nervous system, which plays an important role, not only in almost all regulatory processes within the gastrointestinal tract, but also in adaptive and protective reactions in response to pathological and toxic factors in food.
真菌毒素是由各种真菌物种产生的次级代谢产物。它们通常存在于各种农产品中。存在于食物中的真菌毒素进入生物体后，可能对许多内部器官和系统产生有害影响。首先接触到食物中存在的真菌毒素的胃肠道，特别容易受到这些毒素的有害影响。真菌毒素对胃肠道影响的一个鲜为人知的方面是这些物质对胃肠道神经支配的影响。因此，本研究首次综述了目前关于真菌毒素对发挥重要作用的肠神经系统的影响的知识，肠神经系统不仅在胃肠道内几乎所有的调节过程中起作用，而且在对食物中病理和毒性因素的适应性和保护性反应中也起作用。
