Forsyth D M, Yoshizawa T, Morooka N, Tuite J
Appl Environ Microbiol. 1977 Nov;34(5):547-52. doi: 10.1128/aem.34.5.547-552.1977.
The minimum emetic dose of deoxynivalenol to swine weighing 9 to 10 kg was 0.05 mg/kg of body weight intraperitoneally and 0.1 to 0.2 mg/kg orally. There was no emesis by undosed pigs consuming vomitus from pigs orally dosed with deoxynivalenol or penned with such pigs without access to vomitus. Analysis by gas-liquid chromatography of a sample of Gibberella zeae-infected corn containing about 25% visually damaged kernels indicated 12 ppm of deoxynivalenol. Deoxynivalenol added to feed reduced feed consumption of 20- to 45-kg pigs, ranging from a 20% decrease with 3.6 ppm to 90% reduction with 40 ppm. Loss in weight was associated with feed refusal. Feed refusal, however, was much greater for naturally infected corn samples than for feeds with equal concentrations of the pure compound added, indicating the involvement of an additional factor(s) in the swine refusal response.
对体重9至10千克的猪而言，脱氧雪腐镰刀菌烯醇腹腔注射的最小催吐剂量为0.05毫克/千克体重，口服的最小催吐剂量为0.1至0.2毫克/千克体重。未给药的猪食用经口服脱氧雪腐镰刀菌烯醇的猪的呕吐物，或与这些猪圈养在一起但无法接触到呕吐物时，均未出现呕吐现象。对一份含有约25%肉眼可见受损谷粒的禾谷镰刀菌感染玉米样本进行气液色谱分析，结果表明脱氧雪腐镰刀菌烯醇含量为12 ppm。添加到饲料中的脱氧雪腐镰刀菌烯醇降低了20至45千克猪的采食量，添加量为3.6 ppm时采食量减少20%，添加量为40 ppm时采食量减少90%。体重减轻与采食量减少有关。然而，与添加了同等浓度纯化合物的饲料相比，自然感染玉米样本导致的采食量减少幅度要大得多，这表明猪的拒食反应还涉及其他因素。
