光照疗法对痴呆患者睡眠、激越和抑郁的影响：随机对照试验的系统评价和荟萃分析。
The Effects of Light Therapy on Sleep, Agitation and Depression in People With Dementia: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
机构信息
Department of Rehabilitation Sciences, 26680The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR.
University Research Facility in Behavioral and Systems Neuroscience, 26680The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR.
出版信息
Am J Alzheimers Dis Other Demen. 2023 Jan-Dec;38:15333175231160682. doi: 10.1177/15333175231160682.
OBJECTIVE
To evaluate the effects of light therapy on the alleviation of sleep disturbances, agitation and depression in people with dementia.
METHODS
A search was performed in PubMed, Medline, SCOPUS, Web of Science, EMBASE, CINAHL, Cochrane Library, for studies published between 2000 and 2021.
RESULTS
A total of 4315 articles were screened. Sixteen articles were eligible for this review and 11 randomized controlled studies were included in the meta-analysis. Light therapy had a significant effect on reducing the number of awakenings in sleep ( = 4; 95% CI = -.56, -.05; I = 0%; SMD = -.31) but was not significant in reducing the wake after sleep onset ( = 3; 95% CI = -.14, .59; I = 0%; SMD = .23), agitation ( = 4; 95% CI = -1.02, .45; I = 87%; SMD = -.28) and depression ( = 6; 95% CI = -.80, .40, I = 85%; SMD = -.20).
CONCLUSION
Light therapy appeared to be more effective in terms of alleviating sleep disturbances, rather than reducing agitation and depression, but its long-term effects remain unclear.
目的
评估光照疗法对缓解痴呆患者睡眠障碍、激越和抑郁的效果。
方法
在 PubMed、Medline、SCOPUS、Web of Science、EMBASE、CINAHL、Cochrane 图书馆中进行了检索，检索时间为 2000 年至 2021 年。
结果
共筛选出 4315 篇文章。16 篇文章符合纳入标准，11 项随机对照研究被纳入荟萃分析。光照疗法对减少睡眠中的觉醒次数有显著效果（ = 4；95%CI = -.56，-.05；I = 0%；SMD = -.31），但对减少睡眠起始后的觉醒（ = 3；95%CI = -.14，.59；I = 0%；SMD =.23）、激越（ = 4；95%CI = -1.02，.45；I = 87%；SMD = -.28）和抑郁（ = 6；95%CI = -.80，.40，I = 85%；SMD = -.20）没有显著效果。
结论
光照疗法在缓解睡眠障碍方面似乎更有效，而在减轻激越和抑郁方面则效果不明显，但长期效果尚不清楚。
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