Institute of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.
J Cell Biochem. 2024 Nov;125(11):e30396. doi: 10.1002/jcb.30396. Epub 2023 Mar 16.
The coordinated interaction between mitochondria and lysosomes, mainly manifested by mitophagy, mitochondria-derived vesicles, and direct physical contact, is essential for maintaining cellular life activities. The VPS39 subunit of the homotypic fusion and protein sorting complex could play a key role in the regulation of organelle dynamics, such as endolysosomal trafficking and mitochondria-vacuole/lysosome crosstalk, thus contributing to a variety of physiological functions. The abnormalities of VPS39 and related subunits have been reported to be involved in the pathological process of some diseases. Here, we analyze the potential mechanisms and the existing problems of VPS39 in regulating organelle dynamics, which, in turn, regulate physiological functions and disease pathogenesis, so as to provide new clues for facilitating the discovery of therapeutic targets for mitochondrial and lysosomal diseases.
线粒体和溶酶体之间的协调相互作用，主要表现为自噬、线粒体衍生小泡和直接物理接触，对于维持细胞的生命活动至关重要。同源融合和蛋白质分选复合物的 VPS39 亚基在调节细胞器动力学方面发挥着关键作用，如内溶酶体运输和线粒体-液泡/溶酶体串扰，从而有助于多种生理功能。已经报道了 VPS39 和相关亚基的异常与一些疾病的病理过程有关。在这里，我们分析了 VPS39 调节细胞器动力学的潜在机制和存在的问题，进而调节生理功能和疾病发病机制，从而为促进发现线粒体和溶酶体疾病的治疗靶点提供新的线索。
