College of Public Health, Hebei Medical University, Shijiazhuang, China.
Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China.
AIDS Res Hum Retroviruses. 2023 Aug;39(8):442-451. doi: 10.1089/AID.2022.0173. Epub 2023 Apr 20.
Subtypes circulating recombinant form (CRF)01_AE and C are two human immunodeficiency virus (HIV)-1 strains that are prevalent in different key populations such as men who have sex with men (MSM) in China. Co-circulating of different HIV-1 subtypes is easy to result in the generation of second-generation recombinants. In this study, three new HIV-1 CRF01_AE/C recombinants from three MSMs were detected in Hebei province, China. Phylogenetic tree and recombination analysis showed that the near-full-length genomic of S114 had seven recombination breakpoints, including four C fragments inserted into the CRF01_AE backbone; M363 had six recombination breakpoints, including three C fragments inserted into the CRF01_AE backbone; M162 had eight recombination breakpoints, including four C fragments inserted into the CRF01_AE backbone. Furthermore, phylogenetic tree analysis based on subregion gene fragments also identified this kind of CRF01_AE/C recombinant structure. This study suggests a more complex HIV-1 epidemiological trend in Hebei province, China and the urgency of continuous HIV-1 recombinant strain registry in sexually transmitted populations.
在中国，两种流行于不同重点人群（如男男性行为者）的人类免疫缺陷病毒 1 型（HIV-1）亚型循环重组形式（CRF）01_AE 和 C。不同 HIV-1 亚型的共同流行很容易导致第二代重组体的产生。在这项研究中，在中国河北省从 3 名男男性行为者中检测到了 3 种新的 HIV-1 CRF01_AE/C 重组体。系统进化树和重组分析显示，S114 的全长近基因组有 7 个重组断点，包括 4 个插入 CRF01_AE 骨架的 C 片段；M363 有 6 个重组断点，包括 3 个插入 CRF01_AE 骨架的 C 片段；M162 有 8 个重组断点，包括 4 个插入 CRF01_AE 骨架的 C 片段。此外，基于亚区基因片段的系统进化树分析也鉴定出了这种 CRF01_AE/C 重组结构。本研究表明中国河北省 HIV-1 流行趋势更加复杂，性传播人群中 HIV-1 重组株登记的紧迫性也日益增加。
