在中国河北省男男性行为者中发现的一种新的 HIV-1 CRF68_01B/CRF01_AE 重组形式。
Identification of a New HIV-1 CRF68_01B/CRF01_AE Recombinant Form Among Men Who Have Sex with Men in Hebei Province, China.
机构信息
Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China.
出版信息
AIDS Res Hum Retroviruses. 2022 Oct;38(10):817-821. doi: 10.1089/AID.2022.0067. Epub 2022 Sep 1.
In recent years, homosexual contact has been the most frequent route of human immunodeficiency virus type one (HIV-1) transmission in Hebei, China. The number of circulating recombinant forms (CRFs) and unique recombinant forms found in this key population were more and more. In this study, we identified a novel HIV-1 second-generation recombinant form originated from CRF68_01B and CRF01_AE among men who have sex with men (MSM) through the phylogenetic and recombinant breakpoints analyses based on the near full-length genome. Both CRF68_01B and CRF01_AE were circulating in the Hebei province of China, and this MSM was diagnosed as the recent HIV-1 infection in fact. The result reminds that we should constantly monitor HIV-1 diversity in Hebei and take further effective to control the recombination of not only HIV-1 major strains but also minor strains.
近年来，同性恋接触已成为中国河北地区人类免疫缺陷病毒 1 型（HIV-1）传播的最常见途径。在这一关键人群中发现的循环重组形式（CRF）和独特重组形式的数量越来越多。在这项研究中，我们通过基于近全长基因组的系统进化和重组断点分析，在男男性接触者（MSM）中鉴定出一种源自 CRF68_01B 和 CRF01_AE 的新型 HIV-1 第二代重组形式。CRF68_01B 和 CRF01_AE 均在中国河北省流行，该 MSM 实际上被诊断为近期 HIV-1 感染。该结果提醒我们应不断监测河北地区 HIV-1 的多样性，并进一步采取有效措施，不仅控制 HIV-1 主要株系，而且控制次要株系的重组。
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