Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China.
AIDS Res Hum Retroviruses. 2022 Oct;38(10):817-821. doi: 10.1089/AID.2022.0067. Epub 2022 Sep 1.
In recent years, homosexual contact has been the most frequent route of human immunodeficiency virus type one (HIV-1) transmission in Hebei, China. The number of circulating recombinant forms (CRFs) and unique recombinant forms found in this key population were more and more. In this study, we identified a novel HIV-1 second-generation recombinant form originated from CRF68_01B and CRF01_AE among men who have sex with men (MSM) through the phylogenetic and recombinant breakpoints analyses based on the near full-length genome. Both CRF68_01B and CRF01_AE were circulating in the Hebei province of China, and this MSM was diagnosed as the recent HIV-1 infection in fact. The result reminds that we should constantly monitor HIV-1 diversity in Hebei and take further effective to control the recombination of not only HIV-1 major strains but also minor strains.
近年来，同性恋接触已成为中国河北地区人类免疫缺陷病毒 1 型（HIV-1）传播的最常见途径。在这一关键人群中发现的循环重组形式（CRF）和独特重组形式的数量越来越多。在这项研究中，我们通过基于近全长基因组的系统进化和重组断点分析，在男男性接触者（MSM）中鉴定出一种源自 CRF68_01B 和 CRF01_AE 的新型 HIV-1 第二代重组形式。CRF68_01B 和 CRF01_AE 均在中国河北省流行，该 MSM 实际上被诊断为近期 HIV-1 感染。该结果提醒我们应不断监测河北地区 HIV-1 的多样性，并进一步采取有效措施，不仅控制 HIV-1 主要株系，而且控制次要株系的重组。
