Seli Denis A, Taylor Hugh S
Colby College, Waterville, Maine.
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.
Curr Opin Obstet Gynecol. 2023 Jun 1;35(3):210-215. doi: 10.1097/GCO.0000000000000868. Epub 2023 Mar 14.
Rapid increase in world population accompanied by global industrialization has led to an increase in deployment of natural resources, resulting in growing levels of pollution. Here, we review recent literature on the impact of environmental pollution on human reproductive health and assisted reproduction outcomes, focusing on two of the most common: air pollution and endocrine disruptors.
Air pollution has been associated with diminished ovarian reserve, uterine leiomyoma, decreased sperm concentration and motility. Air pollution also correlates with decreased pregnancy rates in patients undergoing infertility treatment using in-vitro fertilization (IVF). Similarly, Bisphenol A (BPA), a well studied endocrine disrupting chemical, with oestrogen-like activity, is associated with diminished ovarian reserve, and abnormal semen parameters, while clinical implications for patients undergoing infertility treatment remain to be established.
There is convincing evidence that environmental pollutants may have a negative impact on human health and reproductive potential. Air pollutions and endocrine disrupting chemicals found in water and food seem to affect male and female reproductive function. Large-scale studies are needed to determine the threshold values for health impact that may drive targeted policies.
世界人口的快速增长伴随着全球工业化，导致自然资源的开采增加，污染水平不断上升。在此，我们综述了近期关于环境污染对人类生殖健康和辅助生殖结局影响的文献，重点关注两种最常见的污染：空气污染和内分泌干扰物。
空气污染与卵巢储备减少、子宫肌瘤、精子浓度和活力降低有关。空气污染还与接受体外受精（IVF）治疗的不孕症患者的妊娠率降低相关。同样，双酚A（BPA）是一种经过充分研究的具有雌激素样活性的内分泌干扰化学物质，与卵巢储备减少和精液参数异常有关，而对接受不孕症治疗的患者的临床影响仍有待确定。
有令人信服的证据表明，环境污染物可能对人类健康和生殖潜力产生负面影响。水和食物中的空气污染和内分泌干扰化学物质似乎会影响男性和女性的生殖功能。需要进行大规模研究来确定可能推动针对性政策的健康影响阈值。
