College of Nursing, University of South Florida, Tampa, FL, USA.
College of Medicine, University of South Florida, Tampa, FL, USA.
J Hum Lact. 2023 May;39(2):255-277. doi: 10.1177/08903344231156449. Epub 2023 Mar 16.
Human milk is a complex source of nutrition and other bioactives that protects infants from disease, holding a lifetime of beneficial effects. The field of metabolomics provides a robust platform through which we can better understand human milk at a level rarely examined.
To Identify, describe, synthesize, and critically analyze the literature within the past 5 years related to the human milk metabolome.
We conducted a scoping literature review and quality analysis of the recent science reflecting untargeted metabolomic approaches to examining human milk. We searched six databases using the terms "breast milk," "metabolome," "metabolite," and "human milk," Out of more than 1,069 abstracts, we screened and identified 22 articles that met our inclusion criteria.
We extracted data related to the study author, geographic location, research design, analyses, platform used, and results. We also extracted data related to human milk research activities, including collection protocol, infant/maternal considerations, and time. Selected studies focused on a variety of phenotypes, including maternal and infant disease. Investigators used varying approaches to evaluate the metabolome, and differing milk collection protocols were observed.
The human milk metabolome is informed by many factors-which may contribute to infant health outcomes-that have resulted in disparate milk metabolomic profiles. Standardized milk collection and storage procedures should be implemented to minimize degradation. Investigators may use our findings to develop research questions that test a targeted metabolomic approach.
人乳是营养和其他生物活性物质的复杂来源，可保护婴儿免受疾病侵害，产生终身的有益影响。代谢组学领域提供了一个强大的平台，通过该平台，我们可以在很少检查的水平上更好地了解人乳。
识别、描述、综合和批判性分析过去 5 年与人乳代谢组学相关的文献。
我们对反映使用非靶向代谢组学方法检查人乳的最新科学进行了范围广泛的文献回顾和质量分析。我们使用了“母乳”、“代谢组”、“代谢物”和“人乳”等术语，在六个数据库中进行了搜索。在 1069 多个摘要中，我们筛选并确定了符合纳入标准的 22 篇文章。
我们提取了与研究作者、地理位置、研究设计、分析、使用的平台和结果相关的数据。我们还提取了与母乳研究活动相关的数据，包括收集方案、母婴注意事项和时间。选定的研究侧重于各种表型，包括母婴疾病。研究人员使用不同的方法来评估代谢组，并且观察到不同的乳汁代谢组图谱。
人乳代谢组受许多因素的影响，这些因素可能会影响婴儿的健康结果，从而导致乳汁代谢组图谱存在差异。应实施标准化的乳汁收集和储存程序以最大程度地减少降解。研究人员可以利用我们的研究结果来提出测试靶向代谢组学方法的研究问题。
