Dahaghin Ali, Salimibani Milad, Boszczyk Agnieszka, Grasa Jorge, Siedlecki Damian
Department of Optics and Photonics, Wroclaw University of Science and Technology, Wrocław, Poland.
Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain.
PLoS One. 2025 Mar 25;20(3):e0320205. doi: 10.1371/journal.pone.0320205. eCollection 2025.
This study addresses a crucial knowledge gap by investigating the impact of intraocular pressure (IOP) on the wobbling characteristics of the crystalline lens in an ex vivo setting. It utilizes previous validated computational porcine eye models, which offer anatomical and physiological similarities to the human eye. These models incorporate fluid-structure interaction (FSI) to simulate the mechanical interaction between the fluids of the eye and the solid structures. Simulations were conducted under constant mechanical properties and boundary conditions, allowing for precise quantification of lens wobbling behavior with varying IOP levels. Various trends in lens displacement were observed at various IOP levels, revealing significant variations in both magnitude and duration. The results demonstrate the central role of intraocular pressure in influencing lens overshooting during rotational motion, with potential clinical implications. The observed lens displacement patterns, particularly in conditions like glaucoma, underscore the importance of considering IOP as a critical factor in understanding ocular biomechanics. Beyond immediate biomechanical relevance, the study's findings suggest the potential use of the Purkinje imaging system as a non-invasive method for IOP estimation based on lens overshoot as an "inverse solution" strategy. This non-invasive imaging technique offers a promising alternative to traditional methods, minimizing patient discomfort and potentially enhancing measurement precision.
本研究通过在离体环境中研究眼内压（IOP）对晶状体摆动特性的影响，解决了一个关键的知识空白。它利用了先前经过验证的猪眼计算模型，这些模型在解剖学和生理学上与人类眼睛相似。这些模型纳入了流固耦合（FSI）来模拟眼内流体与固体结构之间的机械相互作用。在恒定的力学性能和边界条件下进行模拟，从而能够精确量化不同IOP水平下晶状体的摆动行为。在不同的IOP水平下观察到了晶状体位移的各种趋势，揭示了幅度和持续时间上的显著差异。结果表明眼内压在影响旋转运动期间晶状体过冲方面起着核心作用，具有潜在的临床意义。观察到的晶状体位移模式，特别是在青光眼等情况下，强调了将IOP视为理解眼部生物力学的关键因素的重要性。除了直接的生物力学相关性之外，该研究的结果还表明，基于晶状体过冲作为一种“反解”策略，普尔钦耶成像系统有可能作为一种非侵入性的IOP估计方法。这种非侵入性成像技术为传统方法提供了一种有前景的替代方案，可将患者不适降至最低，并有可能提高测量精度。
