用于快速检测新冠病毒的具有图像分析功能的胆甾相液晶生物传感器平台

Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19.

作者信息

Lin Ping-Yuan, Chung Yi-Wei, Chuang Er-Yuan, Wang Yen-Chieh, Lai Min-Chih, Hsu Yen-Chin, Lin Chun-Che, Hsiao Yu-Cheng

机构信息

Graduate Institute of Biomedical Opto mechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.

Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

出版信息

Front Bioeng Biotechnol. 2023 Feb 28;11:1148446. doi: 10.3389/fbioe.2023.1148446. eCollection 2023.

Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases.