College of Textiles, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, People's Republic of China.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Institute of Functional Materials, Research Base of Textile Materials for Flexible Electronics and Biomedical Applications (China Textile Engineering Society), Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, People's Republic of China.
Nano Lett. 2023 Apr 12;23(7):2927-2937. doi: 10.1021/acs.nanolett.3c00300. Epub 2023 Mar 16.
Electrotherapy is a promising tissue repair technique. However, electrotherapy devices are frequently complex and must be placed adjacent to injured tissue, thereby limiting their clinical application. Here, we propose a general strategy to facilitate tissue repair by modulating endogenous electric fields with nonadjacent (approximately 44 mm) wireless electrotherapy through a 3D-printed entirely soft and bioresorbable triboelectric nanogenerator based stimulator, without any electrical accessories, which has biomimetic mechanical properties similar to those of soft tissue. In addition, the feasibility of using the stimulator to construct an electrical double layer with tissue for nonadjacent wireless electrotherapy was demonstrated by skin and muscle injury models. The treated groups showed significantly improved tissue repair compared with the control group. In conclusion, we developed a promising electrotherapy strategy and may inspire next-generation electrotherapy for tissue repair.
电疗是一种很有前途的组织修复技术。然而，电疗设备通常很复杂，必须放置在受伤组织附近，因此限制了它们的临床应用。在这里，我们提出了一种通用策略，通过基于 3D 打印的完全柔软和可生物吸收的摩擦电纳米发电机的非相邻（约 44mm）无线电疗来调节内源性电场，从而促进组织修复，无需任何电气附件，该发电机具有类似于软组织的仿生机械性能。此外，通过皮肤和肌肉损伤模型证明了使用刺激器在非相邻无线电疗中与组织构建双电层的可行性。与对照组相比，治疗组的组织修复有明显改善。总之，我们开发了一种很有前途的电疗策略，可能会激发下一代用于组织修复的电疗。
