Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, Hong Kong 999077, People's Republic of China.
Nano Lett. 2022 Jul 27;22(14):5944-5953. doi: 10.1021/acs.nanolett.2c01997. Epub 2022 Jul 11.
A combined treatment using medication and electrostimulation increases its effectiveness in comparison with one treatment alone. However, the organic integration of two strategies in one miniaturized system for practical usage has seldom been reported. This article reports an implantable electronic medicine based on bioresorbable microneedle devices that is activated wirelessly for electrostimulation and sustainable delivery of anti-inflammatory drugs. The electronic medicine is composed of a radio frequency wireless power transmission system and a drug-loaded microneedle structure, all fabricated with bioresorbable materials. In a rat skeletal muscle injury model, periodic electrostimulation regulates cell behaviors and tissue regeneration while the anti-inflammatory drugs prevent inflammation, which ultimately enhance the skeletal muscle regeneration. Finally, the electronic medicine is fully bioresorbable, excluding the second surgery for device removal.
联合使用药物和电刺激的治疗方法比单一治疗方法更有效。然而，将两种策略有机地整合到一个小型化系统中用于实际应用的情况很少有报道。本文报道了一种基于可生物吸收微针装置的植入式电子药物，该电子药物可通过无线方式激活进行电刺激和持续输送抗炎药物。这种电子药物由射频无线能量传输系统和负载药物的微针结构组成，均采用可生物吸收材料制造。在大鼠骨骼肌损伤模型中，周期性电刺激调节细胞行为和组织再生，而抗炎药物则防止炎症，从而最终增强骨骼肌再生。最后，电子药物完全可生物吸收，无需进行第二次手术取出装置。
