大白猪中**和**基因的遗传多态性及其与产仔性状的关联
Genetic polymorphisms in and genes and their association with litter traits in Large White pigs.
作者信息
Wu Shun, Xie Jingjing, Zhong Tao, Shen Linyuan, Zhao Ye, Chen Lei, Gan Mailin, Zhang Shunhua, Zhu Li, Niu Lili
机构信息
Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
出版信息
Anim Biotechnol. 2023 Dec;34(9):4713-4720. doi: 10.1080/10495398.2023.2187405. Epub 2023 Mar 16.
The estrogen receptor () gene and follicle-stimulating hormone β () gene are responsible for litter traits. The present study aimed to verify the polymorphisms of and and assess their effects on the litter traits in 201 Large White pigs. Four SNPs (g.C669T, g.A1296G, g.C1665T and g.A1755G) were found in . The TT genotype at g.C1665T locus and AA genotype at g.A1755G locus could significantly increase the total litter size of the first litter of American Large White pigs ( < 0.05). Eight SNPs were found in exon 3 of . The AA genotype at g.A511G locus, AA and AG genotypes at g.A617G locus, CC and CT genotypes at g.C630T locus, CT and TT genotypes at g.C652T locus, CT and TT genotypes at g.C735T locus, AA and AG genotypes at g.A746G, AA and AG genotypes at g.A921G and CT genotype at g.C678T could significantly increase the litter size of different strains of Large White pigs ( < 0.05). Our study revealed that the genetic variations of and were closely related to the litter trait of Large White pigs. Therefore, and genes could be used as molecular markers for the genetic selection of Large White pigs.
雌激素受体（）基因和促卵泡激素β（）基因与产仔性状有关。本研究旨在验证和的多态性，并评估它们对201头大白猪产仔性状的影响。在中发现了4个单核苷酸多态性（g.C669T、g.A1296G、g.C1665T和g.A1755G）。g.C1665T位点的TT基因型和g.A1755G位点的AA基因型可显著增加美系大白猪头胎的总产仔数（<0.05）。在的第3外显子中发现了8个单核苷酸多态性。g.A511G位点的AA基因型、g.A617G位点的AA和AG基因型、g.C630T位点的CC和CT基因型、g.C652T位点的CT和TT基因型、g.C735T位点的CT和TT基因型、g.A746G位点的AA和AG基因型、g.A921G位点的AA和AG基因型以及g.C678T位点的CT基因型可显著增加不同品系大白猪的产仔数（<0.05）。我们的研究表明，和的遗传变异与大白猪的产仔性状密切相关。因此，和基因可作为大白猪遗传选择的分子标记。
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