非糖尿病人群样本中习惯性日常饮酒与全天和特定时间平均血糖水平的关系。
Relationships of habitual daily alcohol consumption with all-day and time-specific average glucose levels among non-diabetic population samples.
机构信息
Department of Social Medicine, Osaka University Graduate School of Medicine.
Osaka Center for Cancer and Cardiovascular Disease Prevention.
出版信息
Environ Health Prev Med. 2023;28:20. doi: 10.1265/ehpm.22-00215.
BACKGROUND
Alcohol consumption is a prevalent behavior that is bi-directionally related to the risk of type 2 diabetes. However, the effect of daily alcohol consumption on glucose levels in real-world situations in the general population has not been well elucidated. This study aimed to clarify the relationship between alcohol consumption and all-day and time-specific glucose levels among non-diabetic individuals.
METHODS
We investigated 913 non-diabetic males and females, aged 40-69 years, during 2018-2020 from four communities across Japan. The daily alcohol consumption was assessed using a self-report questionnaire. All-day and time-specific average glucose levels were estimated from the interstitial glucose concentrations measured using the Flash glucose monitoring system for a median duration of 13 days. Furthermore, we investigated the association between all-day and time-specific average glucose levels and habitual daily alcohol consumption levels, using never drinkers as the reference, and performed multiple linear regression analyses after adjusting for age, community, and other diabetes risk factors for males and females separately.
RESULTS
All-day average glucose levels did not vary according to alcohol consumption categories in both males and females. However, for males, the average glucose levels between 5:00 and 11:00 h and between 11:00 and 17:00 h were higher in moderate and heavy drinkers than in never drinkers, with the difference values of 4.6 and 4.7 mg/dL for moderate drinkers, and 5.7 and 6.8 mg/dL for heavy drinkers. Conversely, the average glucose levels between 17:00 and 24:00 h were lower in male moderate and heavy drinkers and female current drinkers than in never drinkers; the difference values of mean glucose levels were -5.8 for moderate drinkers, and -6.1 mg/dL for heavy drinkers in males and -2.7 mg/dL for female current drinkers.
CONCLUSIONS
Alcohol consumption was associated with glucose levels in a time-dependent biphasic pattern.
背景
饮酒是一种普遍存在的行为，与 2 型糖尿病的风险呈双向相关。然而，在一般人群的现实情况下，每日饮酒量对血糖水平的影响尚未得到充分阐明。本研究旨在阐明非糖尿病个体中饮酒与全天和特定时间血糖水平之间的关系。
方法
我们在 2018 年至 2020 年期间，从日本四个社区调查了 913 名年龄在 40-69 岁的非糖尿病男性和女性。使用自我报告问卷评估每日饮酒量。使用 Flash 血糖监测系统测量的间质葡萄糖浓度来估算全天和特定时间的平均血糖水平，该系统的中位持续时间为 13 天。此外，我们以从不饮酒者为参照，调查了全天和特定时间平均血糖水平与习惯性每日饮酒水平之间的关系，并分别对男性和女性进行了多元线性回归分析，调整了年龄、社区和其他糖尿病危险因素。
结果
男性和女性的全天平均血糖水平均不受饮酒量分类的影响。然而，对于男性，5:00 至 11:00 时和 11:00 至 17:00 时的平均血糖水平在中度和重度饮酒者中高于从不饮酒者，差异值分别为 4.6 和 4.7mg/dL 中度饮酒者，以及 5.7 和 6.8mg/dL 重度饮酒者。相反，17:00 至 24:00 时的平均血糖水平在男性中度和重度饮酒者以及女性当前饮酒者中低于从不饮酒者；男性中度饮酒者的平均血糖水平差值为-5.8，重度饮酒者差值为-6.1mg/dL，女性当前饮酒者差值为-2.7mg/dL。
结论
饮酒与血糖水平呈时间依赖性双相模式相关。
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