Hepatology, Gastroenterology and Infectious Diseases Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Rheumatology and Rehabilitation Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Sci Rep. 2023 Mar 16;13(1):4353. doi: 10.1038/s41598-023-31256-w.
Nonalcoholic fatty liver disease (NAFLD) has been linked with a number of extra hepatic diseases and could be a potential risk factor of decreasing bone mineral density. To determine whether Upper Egyptian patients with NAFLD are at risk of developing osteoporosis. Cross sectional study was done on a total 100 individuals; 50 patients diagnosed with NAFLD (based on ultrasound imaging) crossed-matched with 50 individuals without NAFLD based on age, sex and body mass index. Bone mineral density, serum calcium and phosphorus levels, serum parathyroid hormone, serum vitamin D and fasting insulin level were assessed. Osteoporosis was prevalent in NAFLD patients versus to controls (19/50 vs. 0/50; P < 0.001). There was significant decrease in bone mineral density in NAFLD patients than controls (- 2.29 ± 0.4 vs. - 1.53 ± 0.1; P < 0.001). There was a statistical significance decrease in serum vitamin D and calcium levels in NAFLD patients than controls. Furthermore, vitamin D levels in the NAFLD group was a predictor for osteoporosis (OR 0.614; 95% CI 0.348-0.825). Patients with NAFLD tend to have a significant decrease in bone density, vitamin D, and serum calcium levels than controls.
非酒精性脂肪性肝病（NAFLD）与许多肝外疾病有关，可能是降低骨密度的潜在危险因素。为了确定埃及上尼罗地区的 NAFLD 患者是否有发生骨质疏松的风险。本研究为一项横断面研究，共纳入了 100 人；50 名经超声成像诊断为 NAFLD 的患者（基于年龄、性别和体重指数与 50 名非 NAFLD 患者进行了交叉匹配。评估了骨密度、血清钙和磷水平、甲状旁腺激素、血清维生素 D 和空腹胰岛素水平。与对照组相比，NAFLD 患者的骨质疏松症更为常见（19/50 比 0/50；P<0.001）。与对照组相比，NAFLD 患者的骨密度显著降低（-2.29±0.4 比-1.53±0.1；P<0.001）。与对照组相比，NAFLD 患者的血清维生素 D 和钙水平显著降低。此外，NAFLD 组的维生素 D 水平是骨质疏松症的预测因素（OR 0.614；95%CI 0.348-0.825）。与对照组相比，NAFLD 患者的骨密度、维生素 D 和血清钙水平显著降低。
