Tan Juan, Wang Lin, Li Hong, Wang Honggang, Yang Xiaozhong
Department of General Practice, The Affiliated Huai 'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China.
Department of Health Management Center, The Affiliated Huai 'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China.
Diabetes Metab Syndr Obes. 2025 Jan 17;18:161-171. doi: 10.2147/DMSO.S492060. eCollection 2025.
To investigate the relationship between serum uric acid (SUA) levels and femoral neck bone mineral density (BMD) in patients with metabolic dysfunction-associated fatty liver disease (MAFLD).
This cross-sectional study included 597 adult inpatients with type 2 diabetes mellitus and ultrasonography-confirmed fatty liver disease. Participants were stratified into tertiles based on femoral neck BMD. Gender-stratified linear regression analyses were performed to assess the relationship between SUA and femoral neck BMD. Nonlinear associations were explored using generalized additive models and two-piece linear regression.
No significant linear association was observed between SUA and femoral neck BMD in either gender (all > 0.05). However, after adjusting for confounders, a nonlinear relationship was identified in male patients, with a threshold at 388 μmol/L. The effect sizes for SUA levels below and above this threshold were 0.001 (95% : 0.000 to 0.002, = 0.008) and -0.000 (95% : -0.002 to 0.000, = 0.117), respectively. No nonlinear relationship was observed in female patients.
In male MAFLD patients, SUA levels exhibit a nonlinear relationship with femoral neck BMD, with a positive association observed between 300 μmol/L and 388 μmol/L. This relationship was not observed in female patients, suggesting gender-specific effects of SUA on bone health in MAFLD.
探讨代谢功能障碍相关脂肪性肝病（MAFLD）患者血清尿酸（SUA）水平与股骨颈骨密度（BMD）之间的关系。
这项横断面研究纳入了597例2型糖尿病成年住院患者，且经超声检查确诊为脂肪肝。参与者根据股骨颈骨密度分为三分位数。进行性别分层线性回归分析以评估SUA与股骨颈骨密度之间的关系。使用广义相加模型和两段线性回归探索非线性关联。
无论男性还是女性，SUA与股骨颈骨密度之间均未观察到显著的线性关联（所有P>0.05）。然而，在调整混杂因素后，在男性患者中发现了非线性关系，阈值为388μmol/L。低于和高于该阈值的SUA水平的效应量分别为0.001（95%CI：0.000至0.002，P=0.008）和-0.000（95%CI：-0.002至0.000，P=0.117）。女性患者未观察到非线性关系。
在男性MAFLD患者中，SUA水平与股骨颈骨密度呈非线性关系，在300μmol/L至388μmol/L之间呈正相关。女性患者未观察到这种关系，提示SUA对MAFLD患者骨骼健康的影响存在性别差异。
