衰老对精液参数和精子DNA片段化的影响。
The effects of aging on semen parameters and sperm DNA fragmentation.
作者信息
Pino Víctor, Sanz Antonia, Valdés Nicolás, Crosby Javier, Mackenna Antonio
机构信息
Faculty of Medicine, University of Los Andes, Santiago, Chile.
Environmental Chemist, Department of Epidemiology, Faculty of Obstetrics and Medicine, University of Los Andes, Santiago, Chile.
出版信息
JBRA Assist Reprod. 2020 Jan 30;24(1):82-86. doi: 10.5935/1518-0557.20190058.
INTRODUCTION
This study aimed to look into possible correlations between male age and different sperm parameters derived from semen analysis and sperm deoxyribonucleic acid (DNA) fragmentation.
METHODS
This retrospective descriptive study included 2681 male patients who underwent semen analysis at Clínica Las Condes (CLC), Santiago, Chile, between January 2014 and May 2017; correlations between age and sperm parameters were analyzed.
RESULTS
Males above the age of 50 were significantly more likely to present anomalies in semen volume, sperm concentration, and sperm DNA fragmentation; males aged 41+ years were more likely to have lower sperm concentration levels; males aged 31+ years were more likely to have decreased sperm motility; when concentration was constant, more volume and motility anomalies were seen as age increased; when volume was kept constant, more motility and concentration anomalies were seen as age increased; and when motility was constant, normal semen volumes decreased as age increased.
CONCLUSION
Our study showed that male age significantly affects sperm parameters that might have an impact on male fertility.
引言
本研究旨在探究男性年龄与精液分析得出的不同精子参数以及精子脱氧核糖核酸（DNA）片段化之间可能存在的相关性。
方法
这项回顾性描述性研究纳入了2014年1月至2017年5月期间在智利圣地亚哥的康德诊所（CLC）接受精液分析的2681名男性患者；分析了年龄与精子参数之间的相关性。
结果
50岁以上男性精液量、精子浓度和精子DNA片段化出现异常的可能性显著更高；41岁及以上男性精子浓度水平较低的可能性更大；31岁及以上男性精子活力下降的可能性更大；当浓度恒定时，随着年龄增长，精液量和活力异常情况增多；当精液量保持恒定时，随着年龄增长，活力和浓度异常情况增多；当活力恒定时，正常精液量随着年龄增长而减少。
结论
我们的研究表明，男性年龄显著影响可能对男性生育能力产生影响的精子参数。
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