Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Myopia Control Research, Aichi Medical University Medical School, Nagakute, Aichi, Japan.
Jpn J Ophthalmol. 2023 May;67(3):312-317. doi: 10.1007/s10384-023-00982-z. Epub 2023 Mar 18.
To investigate the intereye correlations between and differences in the rates of visual field (VF) progression in eyes with bilateral open-angle glaucoma.
Retrospective, longitudinal, observational study.
Patients with bilateral open-angle glaucoma with 8 or more reliable 30 - 2 standard automated perimetry tests over a period of more than 2 years were enrolled. The rate of change of the MD (MD slope) was used as the indicator for the rates of VF progression. Descriptive statistics of the absolute intereye difference in the MD slope values were computed. Factors associated with a large intereye difference (> 0.42 dB/year) were explored.
One hundred eighty-eight eyes from 94 patients (56 women) were enrolled. A significant intereye correlation of the rates of visual field progression (P = .002) was found. The mean ± standard deviation and median intereye differences of the MD slope values were 0.29 ± 0.31 and 0.18 dB/year (range: 0-1.41), respectively. The 5th, 10th, 25th, 75th, 90th, and 95th percentiles of intereye differences were 0.01, 0.02, 0.08, 0.42, 0.72, and 0.91 dB/year, respectively. Older age and slower progression were significantly associated with large intereye difference.
A significant intereye correlation in the rate of VF progression was found in eyes with bilateral open-angle glaucoma. We showed the distributions and associated factors of intereye differences in VF progression. These data may be used for improving the estimation of rates of VF progression.
研究双眼开角型青光眼患者视野（VF）进展速度的眼间相关性和差异。
回顾性、纵向、观察性研究。
纳入了 8 次或以上 30-2 标准自动视野计检查，且随访时间超过 2 年的双侧开角型青光眼患者。MD（MD 斜率）的变化率被用作 VF 进展速度的指标。计算了 MD 斜率值的眼间绝对差异的描述性统计数据。探讨了与眼间差异大（>0.42 dB/年）相关的因素。
共纳入 94 例患者（56 名女性）的 188 只眼。发现 VF 进展速度存在显著的眼间相关性（P=0.002）。MD 斜率值的平均（±标准差）和中位数眼间差异分别为 0.29±0.31 和 0.18 dB/年（范围：0-1.41）。眼间差异的第 5、10、25、75、90 和 95 百分位数分别为 0.01、0.02、0.08、0.42、0.72 和 0.91 dB/年。年龄较大和进展较慢与较大的眼间差异显著相关。
在双侧开角型青光眼患者中发现 VF 进展速度存在显著的眼间相关性。我们展示了 VF 进展的眼间差异分布和相关因素。这些数据可用于提高 VF 进展速度的估计。
