Shcherbakov Viacheslav, Denisov Sergey A, Mostafavi Mehran
Institut de Chimie Physique (ICP), CNRS/Université Paris-Saclay 91405 Orsay France
RSC Adv. 2023 Mar 15;13(13):8557-8563. doi: 10.1039/d3ra00443k. eCollection 2023 Mar 14.
In this work, the mechanism of dioxygen reduction catalysed by gold nanoparticles (AuNPs) by two electron donors was investigated, , by sodium ascorbate and hydroethidine, focusing on potential ROS (reactive oxygen species) formation, such as O˙ and HO. According to our results, when AuNPs catalyse the reduction of O, ROS are formed only as intermediates on the surface of nanoparticles, and they are unavoidably reduced to water, catalysed by the AuNPs. Thus, the statement on ROS production in the presence of AuNPs often reported in the literature is excessive. The AuNPs can catalyze the oxidation of electron donors in the cell, , antioxidants causing oxidative stress. Therefore we propose that when explaining damage in the living cells observed in the presence of AuNP, the catalysis of redox reactions by AuNPs must be considered.
在这项工作中，研究了金纳米颗粒（AuNPs）在两种电子供体（抗坏血酸钠和氢乙锭）作用下催化双氧还原的机制，重点关注潜在的活性氧（ROS）形成，如O˙和HO。根据我们的结果，当AuNPs催化O的还原时，ROS仅作为纳米颗粒表面的中间体形成，并且在AuNPs的催化下不可避免地被还原为水。因此，文献中经常报道的关于在AuNPs存在下产生ROS的说法是夸大的。AuNPs可以催化细胞中电子供体的氧化，即抗氧化剂导致氧化应激。因此，我们建议在解释在AuNP存在下观察到的活细胞损伤时，必须考虑AuNPs对氧化还原反应的催化作用。
