• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在X射线照射下，金纳米颗粒催化过氧化氢分解导致羟基自由基产率增加。

Increase of OH radical yields due to the decomposition of hydrogen peroxide by gold nanoparticles under X-ray irradiation.

作者信息

Okazaki Yu, Kusumoto Tamon, Roux Stephane, Hirayama Ryoichi, Fromm Michel, Bazzi Rana, Kodaira Satoshi, Kataoka Jun

机构信息

Graduate School of Advanced Science and Engineering, Waseda University 3-4-1 Okubo, Shinjuku-ku Tokyo 169-8555 Japan.

National Institutes for Quantum Science and Technology (QST) 4-9-1 Anagawa, Inage-ku Chiba 263-8555 Japan

出版信息

RSC Adv. 2024 Mar 20;14(14):9509-9513. doi: 10.1039/d4ra00208c.

DOI:10.1039/d4ra00208c
PMID:38516151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10953845/
Abstract

We elucidate the decomposition mechanism of hydrogen peroxide, which is formed by water radiolysis, by gold nanoparticles (GNPs) under X-ray irradiation. The variations in yields of hydrogen peroxide generated in the presence of GNPs are evaluated using the Ghormley technique. The increase of yields of OH radicals has been quantified using Ampliflu® Red solutions. Almost all hydrogen peroxide generated by irradiation of <25 Gy is decomposed by GNPs, while the yield of OH radicals increases by 1.6 times. The amount of OH radicals thus obtained is almost equivalent to that of the decomposed hydrogen peroxide. The decomposition of hydrogen peroxide is an essential reaction to produce additional OH radicals efficiently in the vicinity of GNPs.

摘要

我们阐明了在X射线照射下，由水辐射分解形成的过氧化氢被金纳米颗粒（GNP）分解的机制。使用戈姆利技术评估了在存在GNP的情况下产生的过氧化氢产率的变化。使用Ampliflu® Red溶液对OH自由基产率的增加进行了定量。照射剂量<25 Gy产生的几乎所有过氧化氢都被GNP分解，而OH自由基的产率增加了1.6倍。由此获得的OH自由基量几乎与分解的过氧化氢量相当。过氧化氢的分解是在GNP附近有效产生额外OH自由基的关键反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/10953845/9524b6ae97ea/d4ra00208c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/10953845/2cbd280eaefa/d4ra00208c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/10953845/ceb4e726a192/d4ra00208c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/10953845/52b0e338998f/d4ra00208c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/10953845/9524b6ae97ea/d4ra00208c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/10953845/2cbd280eaefa/d4ra00208c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/10953845/ceb4e726a192/d4ra00208c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/10953845/52b0e338998f/d4ra00208c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e900/10953845/9524b6ae97ea/d4ra00208c-f4.jpg

相似文献

1
Increase of OH radical yields due to the decomposition of hydrogen peroxide by gold nanoparticles under X-ray irradiation.在X射线照射下，金纳米颗粒催化过氧化氢分解导致羟基自由基产率增加。
RSC Adv. 2024 Mar 20;14(14):9509-9513. doi: 10.1039/d4ra00208c.
2
The contribution of hydrogen peroxide to the radiosensitizing effect of gold nanoparticles.过氧化氢对金纳米颗粒放射增敏作用的贡献。
Colloids Surf B Biointerfaces. 2019 Mar 1;175:606-613. doi: 10.1016/j.colsurfb.2018.12.041. Epub 2018 Dec 17.
3
Gardenia jasminoides extract-capped gold nanoparticles reverse hydrogen peroxide-induced premature senescence.栀子提取物包覆的金纳米粒子可逆转过氧化氢诱导的细胞早衰。
J Photochem Photobiol B. 2016 Nov;164:204-211. doi: 10.1016/j.jphotobiol.2016.09.033. Epub 2016 Sep 28.
4
The effect of oxygen on the radiolysis of tyrosine in aqueous solutions.氧对水溶液中酪氨酸辐射分解的影响。
Radiat Res. 1987 Feb;109(2):206-15.
5
Hydrogen peroxide formation in water during the VUV/UV irradiation process: Impacts and mechanisms of selected anions.在 VUV/UV 辐照过程中水中过氧化氢的形成：选定阴离子的影响和机制。
Environ Res. 2021 Apr;195:110751. doi: 10.1016/j.envres.2021.110751. Epub 2021 Jan 17.
6
A novel property of gold nanoparticles: Free radical generation under microwave irradiation.金纳米颗粒的一种新特性：微波辐射下产生自由基。
Med Phys. 2016 Apr;43(4):1598. doi: 10.1118/1.4942811.
7
OH radicals and oxidizing products in the gamma radiolysis of water.水的γ辐解中的羟基自由基和氧化产物。
Radiat Res. 2000 Feb;153(2):196-200. doi: 10.1667/0033-7587(2000)153[0196:oraopi]2.0.co;2.
8
Mammalian cells are not killed by DNA single-strand breaks caused by hydroxyl radicals from hydrogen peroxide.哺乳动物细胞不会被过氧化氢产生的羟基自由基所导致的DNA单链断裂杀死。
Radiat Res. 1985 Sep;103(3):383-92.
9
Effect of pH on H2O2 production in the radiolysis of water.pH 值对水辐射分解中产 H2O2 的影响。
J Phys Chem A. 2011 Feb 10;115(5):700-8. doi: 10.1021/jp1099927. Epub 2011 Jan 14.
10
Pulse radiolysis of the DNA-binding bisbenzimidazole derivatives Hoechst 33258 and 33342 in aqueous solutions.DNA结合性双苯并咪唑衍生物Hoechst 33258和33342在水溶液中的脉冲辐解
Int J Radiat Biol. 2000 Sep;76(9):1157-66. doi: 10.1080/09553000050134393.

本文引用的文献

1
A mechanistic study of gold nanoparticles catalysis of O reduction by ascorbate and hydroethidine, investigating reactive oxygen species reactivity.一项关于金纳米颗粒催化抗坏血酸和氢乙啶还原氧的机理研究，探究活性氧的反应活性。
RSC Adv. 2023 Mar 15;13(13):8557-8563. doi: 10.1039/d3ra00443k. eCollection 2023 Mar 14.
2
Significant changes in yields of 7-hydroxy-coumarin-3-carboxylic acid produced under FLASH radiotherapy conditions.在FLASH放射治疗条件下产生的7-羟基香豆素-3-羧酸产量发生显著变化。
RSC Adv. 2020 Oct 27;10(63):38709-38714. doi: 10.1039/d0ra07999e. eCollection 2020 Oct 15.
3
The mechanism of organic radical oxidation catalysed by gold nanoparticles.
金纳米颗粒催化的有机自由基氧化机制。
Phys Chem Chem Phys. 2021 Dec 1;23(46):26494-26500. doi: 10.1039/d1cp03875c.
4
Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions.金属纳米颗粒在放射治疗中的应用路线图：现状、转化挑战和未来方向。
Phys Med Biol. 2020 Oct 22;65(21):21RM02. doi: 10.1088/1361-6560/ab9159.
5
The contribution of hydrogen peroxide to the radiosensitizing effect of gold nanoparticles.过氧化氢对金纳米颗粒放射增敏作用的贡献。
Colloids Surf B Biointerfaces. 2019 Mar 1;175:606-613. doi: 10.1016/j.colsurfb.2018.12.041. Epub 2018 Dec 17.
6
Quantification of hydroxyl radicals and solvated electrons produced by irradiated gold nanoparticles suggests a crucial role of interfacial water.辐照金纳米粒子产生的羟基自由基和溶剂化电子的定量研究表明界面水起着至关重要的作用。
J Colloid Interface Sci. 2018 Sep 1;525:31-38. doi: 10.1016/j.jcis.2018.04.017. Epub 2018 Apr 5.
7
Mechanism of oxidative conversion of Amplex® Red to resorufin: Pulse radiolysis and enzymatic studies.Amplex® Red氧化转化为试卤灵的机制：脉冲辐解和酶学研究。
Free Radic Biol Med. 2016 Jun;95:323-32. doi: 10.1016/j.freeradbiomed.2016.03.027. Epub 2016 Mar 26.
8
Imaging and radiation effects of gold nanoparticles in tumour cells.金纳米颗粒在肿瘤细胞中的成像及辐射效应
Sci Rep. 2016 Jan 20;6:19442. doi: 10.1038/srep19442.
9
A new mechanism for hydroxyl radical production in irradiated nanoparticle solutions.辐照纳米颗粒溶液中羟基自由基产生的新机制。
Small. 2014 Aug 27;10(16):3338-46. doi: 10.1002/smll.201400110. Epub 2014 May 26.
10
The in vivo radiosensitizing effect of gold nanoparticles based MRI contrast agents.基于金纳米粒子的磁共振成像对比剂的体内放射增敏作用。
Small. 2014 Mar 26;10(6):1116-24. doi: 10.1002/smll.201470036.