Gavrankapetanovic Fatima, Sljivo Armin, Dadic Ilma, Mehmedbasic Naida
Clinical Center of University of Sarajevo, University of Sarajevo, Sarajevo, Bosnia and Hercegovina.
Emergency Medicine Department of Canton Sarajevo, Sarajevo, Bosnia and Herzegovina.
Mater Sociomed. 2022 Dec;34(4):260-263. doi: 10.5455/msm.2022.34.260-263.
Human papillomaviruses (HPV) are one of the most prevalent causes of cervical, anal, and oral cancer, and it is believed that nearly all sexually active males and females have been infected with HPV at some point in their lives.
The purpose of this study is to highlight epidemiological characteristics of the age and genotypical incidence of HPV infection among females in Canton Sarajevo during a 10-year period.
This cross-sectional study was conducted in the period between January 2012 and December 2021 at the medical institutions "Zavod za Ginekologiju, Perinatologiju i Neplodnost "Mehmedbašić" among females who were admitted for a routine gynaecological exam in Canton Sarajevo in Bosnia and Herzegovina.
In total, 1517 patients who reported typical sexarche at 18.35±1.92, having one 721 (47.5%) sexual partner, regular use of contraceptive methods 820 (54.5%) with male condom 513 (62.6%) being the dominant choice of contraception and having gynacological hereditary oncological positive history 141 (9.3%), were included in the study from which 653 (43.05%) patients had positive HPV test and 864 (56.95%) had negative HPV results. HPV positive patients, 386 (59.1%) were infected either with one type of virus only, while 267 (40.9%) patients were infected with multiple virus strains where we have identified 166 virus strain combinations. Analysis showed that the patients infected by only one virus strain were one of next specific HPV viruses: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68. HPV-16 was the predominately strain 16 (22.5%) identified among all the patients. Mean age of HPV positive patients was 33.38±7.85, ranging from 18 to 61 years.
This study highlights the significance of the most frequent HPV high-risk strains (HPV-16, -18, -31.-33,-45,-52, and -58) among the Bosnia and Herzegovina population as one of the most common cancer-causing strains worldwide.
人乳头瘤病毒（HPV）是宫颈癌、肛门癌和口腔癌最常见的病因之一，据信几乎所有有性行为的男性和女性在其生命中的某个阶段都曾感染过HPV。
本研究的目的是突出10年间萨拉热窝州女性HPV感染的年龄和基因型发病率的流行病学特征。
这项横断面研究于2012年1月至2021年12月期间在波斯尼亚和黑塞哥维那萨拉热窝州的“Mehmedbašić妇产科、围产医学和不孕不育中心”医疗机构对因常规妇科检查入院的女性进行。
共有1517名患者纳入研究，这些患者报告初潮年龄为18.35±1.92岁，有1名性伴侣的721人（47.5%），经常使用避孕方法的820人（54.5%），其中男性避孕套513人（62.6%）是主要避孕选择，有妇科遗传性肿瘤阳性病史的141人（9.3%），其中653人（43.05%）HPV检测呈阳性，864人（56.95%）HPV检测结果为阴性。HPV阳性患者中，386人（59.1%）仅感染一种病毒，而267人（40.9%）感染多种病毒株，共鉴定出166种病毒株组合。分析表明，仅感染一种病毒株的患者感染的是以下特定HPV病毒之一：16、18、31、33、35、39、45、51、52、56、58、59、66和68。HPV-16是所有患者中鉴定出的主要毒株（22.5%）。HPV阳性患者的平均年龄为33.38±7.85岁，年龄范围为18至61岁。
本研究强调了波斯尼亚和黑塞哥维那人群中最常见的HPV高危毒株（HPV-16、-18、-31、-33、-45、-52和-58）作为全球最常见的致癌毒株之一的重要性。
