Santos Maria Inês, Sousa Mafalda, Cerqueira Paula, Ambrioso Inês, Moniz Ramos Mariana
Internal Medicine, Hospital Distrital de Santarém, Santarém, PRT.
Cureus. 2023 Mar 17;15(3):e36281. doi: 10.7759/cureus.36281. eCollection 2023 Mar.
Acute generalized exanthematous pustulosis (AGEP) is a rare and severe skin disorder induced in more than 90% of cases by an adverse drug reaction. This condition is defined by an acute growth of numerous, pin-head-sized, non-follicular pustules on a background of edematous erythema that starts on the face or in the armpits and groin. It is accompanied by fever and increased inflammatory markers. We present a case of a 39-year-old male, admitted to the internal medicine department due to Streptococcus pneumoniae meningitis treated with ceftriaxone, who developed erythema covered with small sterile pustules in the face, neck, and axilla four days after antibiotic treatment. The clinical and pathological correlations confirmed the diagnosis, and the dermatosis resolved after discontinuing the drug and systemic corticosteroid treatment. Early recognition of this drug-induced dermatosis is crucial for adequate treatment.
急性泛发性脓疱性皮病（AGEP）是一种罕见且严重的皮肤疾病，90%以上的病例由药物不良反应引起。这种病症的定义是在面部、腋窝或腹股沟出现的水肿性红斑背景上，迅速出现大量针头大小的非毛囊性脓疱。它伴有发热和炎症标志物升高。我们报告一例39岁男性，因肺炎链球菌脑膜炎入住内科，接受头孢曲松治疗，抗生素治疗四天后，面部、颈部和腋窝出现覆盖小无菌脓疱的红斑。临床和病理相关性证实了诊断，停药并进行全身性皮质类固醇治疗后，皮肤病得到缓解。早期识别这种药物性皮肤病对于充分治疗至关重要。
