Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
J Med Life. 2023 Feb;16(2):267-276. doi: 10.25122/jml-2021-0294.
A double-blind clinical trial was conducted to examine the effect of concentrated growth factor (CGF), a new generation of platelet derivatives, on the healing outcome of maxillary sinus floor augmentation during maxillary sinus lift surgery. The study included 9 patients referred to the Tabriz University, Faculty of Dentistry, aged 30-80 years, with bilateral posterior partial edentulous or edentulous maxilla who underwent the procedure using a split-mouth technique. After lifting the Schneiderian membrane, bovine xenograft was randomly applied on one side (for example, left maxillary sinus) and CGF on the other side (for example, right maxillary sinus). Results from alizarin red and hematoxylin-eosin staining methods showed that the percentage of bone formed in the CGF group (112.41±26.34% and 96.16±24.49%, respectively) was significantly higher than in the control group (64.99±24.96% and 60.16±16.39%, respectively) (P<0.05). In addition, after 6 months, the amount of residual graft material in the control group (xenograft) was significantly higher than in the CGF group (P<0.05). These findings demonstrate that the use of CGF during open sinus lift surgery is reliable for the placement of dental implants.
一项双盲临床试验旨在研究新一代血小板衍生物浓缩生长因子（CGF）对上颌窦提升术中上颌窦底骨增量愈合结果的影响。该研究纳入了 9 名来自大不里士大学牙科学院的患者，年龄在 30-80 岁之间，双侧后牙部分缺失或全口无牙，采用分侧技术进行手术。提起黏膜后，将牛异种移植物随机应用于一侧（例如左侧上颌窦），CGF 应用于另一侧（例如右侧上颌窦）。茜素红和苏木精-伊红染色方法的结果表明，CGF 组形成的骨百分比（分别为 112.41±26.34%和 96.16±24.49%）明显高于对照组（分别为 64.99±24.96%和 60.16±16.39%）（P<0.05）。此外，6 个月后，对照组（异种移植物）中残留移植物材料的量明显高于 CGF 组（P<0.05）。这些发现表明，在上颌窦开放提升术中使用 CGF 对于种植体的放置是可靠的。
