Feng Yanping, Wu Mingzhen, Zhang Haidong, Xu He, Li Huili, Chen Dongmin, Jiang Hongyi, Chang Jiang, Dong Zhihong, Yang Chen
College of Mechanical Engineering, Chengdu University, Chengdu, Sichuan, China.
Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Front Bioeng Biotechnol. 2023 Mar 3;11:1158007. doi: 10.3389/fbioe.2023.1158007. eCollection 2023.
In clinical practice, the utilization of antibiotics is still the main approach for the treatment of wound contamination, which lacks the ability to accelerate wound healing and arises the global concern of antimicrobial resistance. Plenty of alternative methods have been explored in recent years due to the fast development of material science. Here, CuO/SiO nanowires (CuSi NWs) with good near-infrared (NIR) photothermal conversion ability are synthesized by a one-step hydrothermal method. The as-prepared CuSi NWs possess excellent antibacterial ability against both () and (), which could be enhanced by the assistance of mild photothermal therapy (PTT). Moreover, CuSi NWs at suitable concentrations can promote proliferation, migration, and angiogenic gene expression of human umbilical vein endothelial cells (HUVECs), exhibiting a remarkable pro-vascularization ability. The mouse infect model further proves that the CuSi NWs might be a good candidate for the treatment of infected wounds as the high antibacterial efficiency and accelerated wound healing is obtained.
在临床实践中，使用抗生素仍然是治疗伤口感染的主要方法，但这种方法缺乏促进伤口愈合的能力，并且引发了全球对抗菌素耐药性的关注。近年来，由于材料科学的快速发展，人们探索了许多替代方法。在此，通过一步水热法合成了具有良好近红外（NIR）光热转换能力的CuO/SiO纳米线（CuSi NWs）。所制备的CuSi NWs对（）和（）均具有优异的抗菌能力，在温和的光热疗法（PTT）辅助下，抗菌能力可得到增强。此外，合适浓度的CuSi NWs可以促进人脐静脉内皮细胞（HUVECs）的增殖、迁移和血管生成基因表达，表现出显著的促血管生成能力。小鼠感染模型进一步证明，CuSi NWs可能是治疗感染伤口的良好候选材料，因为它具有高抗菌效率并能加速伤口愈合。
