Kim Young Keun, Kim Eui Hyeok
Department of Internal Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea.
Department of Obstetrics and Gynecology, CHA Ilsan Medical Center, CHA University School of Medicine, Goyang, Korea.
Obstet Gynecol Sci. 2023 May;66(3):149-160. doi: 10.5468/ogs.23001. Epub 2023 Mar 20.
Current evidence suggests that severe acute respiratory syndrome coronavirus 2 infection is associated with an increased incidence of adverse severe maternal and perinatal outcomes. However, vertical transmission is rare. The management of pregnant women with coronavirus disease 2019 (COVID-19) is similar to that of non-pregnant women, and effective treatments, including antiviral therapy, dexamethasone, and prophylactic anticoagulation should not be withheld during pregnancy. During the early COVID-19 pandemic period, the management of pregnant women was often delayed until the polymerase chain reaction (PCR) results came out or due to close contact, even among those without symptoms. Out of concern for the spread of infection, cesarean sections were performed instead of vaginal birth, since infection could have led to an increase in maternal and neonatal morbidities. Additionally, if the maternal PCR test was positive, the neonate was quarantined, and despite infectivity decreasing 10 days after symptom onset. It is necessary to ease the strict measures of infection control in the field of obstetrics. The presence or absence of maternal COVID-19 symptoms should be identified to stratify the risk, and vaginal delivery can be attempted in asymptomatic women with low infectivity. With more women being vaccinated safety data about vaccination is rapidly accumulating and no concerns have been detected. Globally, COVID-19 vaccines are recommended even during pregnancy. In order to prepare for future pandemics, it is necessary to apply lessons learned from this pandemic. Policymakers and healthcare leaders must determine efficient and effective strategies for preserving safe maternal care, even during an ongoing global emergency.
目前的证据表明,严重急性呼吸综合征冠状病毒2感染与孕产妇和围产期不良结局的发生率增加有关。然而,垂直传播很少见。2019冠状病毒病(COVID-19)孕妇的管理与非孕妇相似,在孕期不应停止使用包括抗病毒治疗、地塞米松和预防性抗凝在内的有效治疗方法。在COVID-19大流行早期,即使是无症状的孕妇,其管理也常常延迟到聚合酶链反应(PCR)结果出来或因密切接触而延迟。出于对感染传播的担忧,进行剖宫产而非阴道分娩,因为感染可能会导致孕产妇和新生儿发病率增加。此外,如果母亲的PCR检测呈阳性,新生儿会被隔离,尽管症状出现10天后传染性会降低。有必要放宽产科领域严格的感染控制措施。应确定母亲是否有COVID-19症状以分层风险,对于传染性低的无症状女性可尝试阴道分娩。随着越来越多的女性接种疫苗,关于疫苗接种的安全数据正在迅速积累,尚未发现问题。在全球范围内,即使在孕期也建议接种COVID-19疫苗。为应对未来的大流行,有必要吸取这次大流行的经验教训。政策制定者和医疗保健领导者必须确定有效策略,即使在持续的全球紧急情况下,也要确保安全的孕产妇护理。