2005年至2017年间意大利特定年龄和性别的肺动脉高压死亡率趋势。

Trends in age-specific and sex-specific pulmonary hypertension mortality in Italy between 2005 and 2017.

作者信息

Zuin Marco, Bilato Claudio, Rigatelli Gianluca, Quadretti Laura, Roncon Loris

机构信息

Department of Cardiology, West Vicenza Hospital, Arzignano, Vicenza.

Department of Translational Medicine, University of Ferrara, Ferrara.

出版信息

J Cardiovasc Med (Hagerstown). 2023 May 1;24(5):289-296. doi: 10.2459/JCM.0000000000001457. Epub 2023 Mar 17.

DOI:10.2459/JCM.0000000000001457

PMID:36938812

Abstract

AIMS

Data regarding the pulmonary hypertension (PH)-related mortality and relative trends in the Italian population remain scant. We sought to assess the PH mortality rates and relative trends among the Italian population between 2005 and 2017.

METHODS

Data regarding the cause-specific mortality and population size by sex in 5-year age groups were extracted from the WHO global mortality database. The age-standardized mortality rates, with relative 95% confidence intervals (CIs), also stratified by sex, were using the direct method. Joinpoint regression analyses were used to identify periods with statistically distinct log linear trends in PH-related death rates. To calculate nationwide annual trends in DCM-related mortality, we assessed the average annual percentage change (AAPC) and relative 95% CIs.

RESULTS

In Italy, the PH age-standardized annual mortality rate decreased from 2.34 (95% CI: 2.32-2.36) deaths per 100 000 to 1.51 (95% CI: 1.48-1.53) deaths per 100 000 population. Over the entire period, men had higher PH-related mortality rates than women. Moreover, the PH-related mortality trend rose with a seemingly exponential distribution with a similar trend among male and female individuals. Joinpoint regression analysis revealed a linear significant decrease in age-standardized PH-related mortality from 2005 to 2017 [AAPC: -3.1% (95% CI: -3.8 to -2.5), P < 0.001] in the entire Italian population. However, the decline was more pronounced among men [AAPC: -5.0 (95% CI: -6.1 to -3.9), P < 0.001] compared with women [AAPC: -1.5 (95% CI: -2.3 to -0.7), P = 0.001].

CONCLUSION

In Italy, the PH-related mortality rates linearly declined from 2005 to 2017.

摘要

目的

关于意大利人群中肺动脉高压（PH）相关死亡率及相对趋势的数据仍然匮乏。我们试图评估2005年至2017年意大利人群中的PH死亡率及相对趋势。

方法

从世界卫生组织全球死亡率数据库中提取按性别划分的5岁年龄组特定病因死亡率和人口规模数据。采用直接法计算年龄标准化死亡率及相对95%置信区间（CI），并按性别分层。采用Joinpoint回归分析确定PH相关死亡率具有统计学显著差异的对数线性趋势的时期。为计算全国范围内扩张型心肌病（DCM）相关死亡率的年度趋势，我们评估了平均年度百分比变化（AAPC）及相对95%CI。

结果

在意大利，PH年龄标准化年度死亡率从每10万人2.34例（95%CI：2.32 - 2.36）死亡降至每10万人1.51例（95%CI：1.48 - 1.53）死亡。在整个研究期间，男性的PH相关死亡率高于女性。此外，PH相关死亡率趋势呈近似指数分布上升，男性和女性个体趋势相似。Joinpoint回归分析显示，2005年至2017年整个意大利人群中年龄标准化PH相关死亡率呈线性显著下降[AAPC：-3.1%（95%CI：-3.8至-2.5），P < 0.001]。然而，与女性相比[AAPC：-1.5（95%CI：-2.3至-0.7），P = 0.001]，男性的下降更为明显[AAPC：-5.0（95%CI：-6.1至-3.9），P < 0.001]。