Department of Translational Medicine.
Cardiology Unit, Sant'Anna University Hospital, University of Ferrara, Ferrara, Italy.
J Cardiovasc Med (Hagerstown). 2023 Sep 1;24(9):604-611. doi: 10.2459/JCM.0000000000001519. Epub 2023 Jul 5.
We sought to assess the atrial fibrillation/flutter (AF/AFL) mortality rates and relative trends among the Italian population between 2003 and 2017.
Data regarding the cause-specific mortality and population size by sex in 5-year age groups were extracted from the World Health Organization (WHO) global mortality database. Decedents reporting the codes I48 were extracted accordingly to the International Classification of Disease-10 (ICD-10) coding system. The age-adjusted mortality rates (AAMRs), with relative 95% confidence intervals (CIs), also stratified by sex, were determined using the direct method. Joinpoint regression analyses were used to identify periods with statistically distinct log linear trends in AF/AFL-related death rates. To calculate nationwide annual trends in AF/AFL-related mortality, we assessed the average annual percentage change (AAPC) and relative 95% CIs.
Over the study period, 90 623 (57 109 females) AF-related deaths were recorded. The AF/AFL AAMR increased from 8.1 (95% CI: 7.8-8.2) deaths per 100 000 to 18.7 (16.9-20.0) deaths per 100 000 population. Joinpoint regression analysis revealed a linear increase in age-standardized AF/AFL-related mortality [AAPC: +3.6 (95% CI: 3.0-4.3, P < 0.0001)] in the entire Italian population. Moreover, the mortality rate increased with age, showing a seemingly exponential distribution with a similar trend between males and females. Although the increase was more pronounced among women [AAPC: +3.7 (95% CI: 3.1-4.3, P < 0.0001)] compared with men [AAPC: +3.4 (95% CI: 2.8-4.0, P < 0.0001)], the difference did not reach statistical significance ( P = 0.16).
In Italy, the AF/AFL-related mortality rates linearly increased from 2003 to 2017.
我们旨在评估 2003 年至 2017 年间意大利人群中心房颤动/房扑（AF/AFL）的死亡率和相对趋势。
从世界卫生组织（WHO）全球死亡率数据库中提取了按性别和 5 岁年龄组划分的特定死因死亡率和人口规模数据。根据国际疾病分类-10（ICD-10）编码系统，提取报告代码 I48 的死者。使用直接法确定年龄调整死亡率（AAMR）及其 95%置信区间（CI），并按性别分层。使用 Joinpoint 回归分析确定 AF/AFL 相关死亡率具有统计学显著的对数线性趋势的时间段。为了计算全国范围内 AF/AFL 相关死亡率的年度趋势，我们评估了平均年百分比变化（AAPC）及其 95%CI。
在研究期间，记录了 90623 例（57109 例女性）与 AF 相关的死亡。AF/AFL 的 AAMR 从每 100000 人 8.1（95%CI：7.8-8.2）例死亡增加到每 100000 人 18.7（16.9-20.0）例死亡。Joinpoint 回归分析显示，意大利全人群的年龄标准化 AF/AFL 相关死亡率呈线性增加[AAPC：+3.6（95%CI：3.0-4.3，P<0.0001)]。此外，死亡率随年龄增长而增加，呈现出类似的趋势，男性和女性之间呈指数分布。尽管女性的增长率更高[AAPC：+3.7（95%CI：3.1-4.3，P<0.0001)]，但与男性[AAPC：+3.4（95%CI：2.8-4.0，P<0.0001)]相比，差异无统计学意义（P=0.16）。
在意大利，从 2003 年到 2017 年，AF/AFL 相关死亡率呈线性上升。
