Department of Translational Medicine, University of Ferrara, Ferrara.
Department of Cardiology, West Vicenza Hospital, Arzignano.
J Cardiovasc Med (Hagerstown). 2023 Aug 1;24(8):530-536. doi: 10.2459/JCM.0000000000001512. Epub 2023 Jun 26.
Data regarding the dilated cardiomyopathy (DCM)-related mortality and relative time trends in the Italian population remain scant. We sought to assess the DCM mortality rates and relative trends among the Italian population between 2005 and 2017.
Annual death rates by sex and 5-year age group were extracted from the WHO global mortality database. The age-standardized mortality rates, with relative 95% confidence intervals (95% CIs), also stratified by sex, were calculated using the direct method. Joinpoint regression analyses were used to identify periods with statistically distinct log linear trends in DCM-related death rates. To calculate nationwide annual trends in DCM-related mortality, we assessed the average annual percentage change (AAPC) and relative 95% CIs.
In Italy, the DCM age-standardized annual mortality rate decreased from 4.99 (95% CI: 4.97-5.02) deaths per 100 000 to 2.51 (95% CI: 2.49-2.52) deaths per 100 000 population. Over the entire period, men had a higher DCM-related mortality rates than women. Moreover, the mortality rate increased with age, with a seemingly exponential distribution and showing a similar trend among men and women. Joinpoint regression analysis revealed a linear decrease in age-standardized DCM-related mortality from 2005 to 2017 [AAPC: -5.1% (95% CI: -5.9 to -4.3, P < 0.001)] in the entire Italian population. However, the decline was more pronounced among women [AAPC: -5.6 (95% CI: -6.4 to -4.8, P < 0.001)] compared with men [AAPC: -4.9 (95% CI: -5.8 to -4.1, P < 0.001)].
In Italy, the DCM-related mortality rates linearly declined from 2005 to 2017.
关于意大利人群中扩张型心肌病（DCM）相关死亡率和相对时间趋势的数据仍然很少。我们旨在评估 2005 年至 2017 年间意大利人群中 DCM 的死亡率和相对趋势。
从世界卫生组织全球死亡率数据库中提取按性别和 5 岁年龄组划分的年度死亡率。使用直接法计算标准化死亡率，95%置信区间（95%CI）和按性别分层。使用 Joinpoint 回归分析确定 DCM 相关死亡率存在统计学显著对数线性趋势的时期。为了计算 DCM 相关死亡率的全国年度趋势，我们评估了平均年变化百分比（AAPC）和 95%CI。
在意大利，DCM 的年龄标准化年死亡率从每 100000 人 4.99（95%CI：4.97-5.02）下降到每 100000 人 2.51（95%CI：2.49-2.52）。在整个研究期间，男性的 DCM 相关死亡率高于女性。此外，死亡率随年龄增长而增加，呈指数分布，男性和女性的趋势相似。Joinpoint 回归分析显示，2005 年至 2017 年，年龄标准化 DCM 相关死亡率呈线性下降[AAPC：-5.1%（95%CI：-5.9 至-4.3，P<0.001)]在整个意大利人群中。然而，与男性相比[AAPC：-5.6（95%CI：-6.4 至-4.8，P<0.001)]，女性的下降更为明显[AAPC：-4.9（95%CI：-5.8 至-4.1，P<0.001)]。
在意大利，2005 年至 2017 年，DCM 相关死亡率呈线性下降。
