Meyer R E, Page R L, Thrall D E, Dewhirst M W, Vose D L
Cancer Res. 1986 Nov;46(11):5599-601.
Infusion rates for atracurium were calculated from multiple bolus injection data for normothermic (38 degrees C; n = 4) and hyperthermic (42 degrees C; n = 14) dogs anesthetized with thiopental and oxymorphone while undergoing whole-body hyperthermia treatment. The calculated infusion rate for atracurium at 38 degrees C was 6.2 +/- 0.3 micrograms/kg/min and the calculated infusion rate at 42 degrees C was 8.5 +/- 0.4 micrograms/kg/min. Infusion of atracurium at the calculated infusion rate of 8.5 micrograms/kg/min produced an estimated 90-100% neuromuscular blockade during heating from 38-42 degrees C and at 42 degrees C. Following discontinuation of the infusion and cooling to 38 degrees C, neuromuscular function returned to normal within 20 min with no evidence of recurarization. Atracurium infusion rates appear to be linear and related to body temperature from 26-42 degrees C. Clinically useful neuromuscular blockade in dogs may be obtained during whole-body hyperthermia by utilizing the 42 degrees C atracurium infusion rate throughout the 38-42 degrees C heating phase.
在硫喷妥钠和羟吗啡酮麻醉下，对接受全身热疗的正常体温（38摄氏度；n = 4）和高温（42摄氏度；n = 14）犬进行多次推注注射，据此计算阿曲库铵的输注速率。38摄氏度时阿曲库铵的计算输注速率为6.2±0.3微克/千克/分钟，42摄氏度时的计算输注速率为8.5±0.4微克/千克/分钟。以8.5微克/千克/分钟的计算输注速率输注阿曲库铵，在从38摄氏度加热至42摄氏度以及在42摄氏度时，估计产生90 - 100%的神经肌肉阻滞。输注停止并冷却至38摄氏度后，神经肌肉功能在20分钟内恢复正常，无再次箭毒化的迹象。阿曲库铵输注速率在26 - 42摄氏度范围内似乎呈线性且与体温相关。在全身热疗期间，通过在38 - 42摄氏度加热阶段全程采用42摄氏度时阿曲库铵的输注速率，可在犬身上获得临床上有用的神经肌肉阻滞。
