Greenstein A J, Gennuso R, Sachar D B, Aufses A H
Department of Surgery, Mount Sinai School of Medicine of the City University of New York, New York.
Int J Colorectal Dis. 1987 Nov;2(4):201-2. doi: 10.1007/BF01649505.
Free perforation of cancer in Crohn's disease is exceedingly rare. Three cases were found among 1010 patients admitted to Mount Sinai Hospital between 1960 and 1980. Free perforation of cancer occurs late in the course of Crohn's disease between the second and third decades of disease, whereas spontaneous free perforation usually occurs within the first 5 years. Cancer-related perforation is associated with weight loss, mass and fistula, and carries a poor prognosis.
克罗恩病并发癌性游离穿孔极为罕见。1960年至1980年间，在西奈山医院收治的1010例患者中发现了3例。癌性游离穿孔发生在克罗恩病病程的后期，即发病后的第二个十年到第三个十年之间，而自发性游离穿孔通常发生在发病后的前5年内。癌相关穿孔与体重减轻、肿块及瘘管有关，预后较差。
