Department of Chemistry, University of North Bengal, Darjeeling, West Bengal, 734013, India.
Department of Chemistry, Indian Institute of Technology, Kharagpur, 721302, India.
Talanta. 2023 Jun 1;258:124448. doi: 10.1016/j.talanta.2023.124448. Epub 2023 Mar 14.
Fast and precise identification of toxic G-series nerve agents in the solution and vapor phase is urgently needed to save human beings from unwanted wars and terrorist attacks, which is challenging to execute practically. In this article, we have designed and synthesized a sensitive and selective phthalimide-based chromo-fluorogenic sensor, DHAI, by a simple condensation process that shows ratiometric and turns on chromo-fluorogenic behavior towards Sarin gas mimic diethylchlorophosphate (DCP) in liquid and vapor phases, respectively. A colorimetric change, from yellow to colorless, is observed in the DHAI solution due to the introduction of DCP in daylight. A remarkable cyan color photoluminescence enhancement is noticed in the presence of DCP in the DHAI solution, which is observable to the naked under a portable 365 nm UV lamp. The mechanistic aspects of the detection of DCP by employing DHAI have been revealed by time-resolved photoluminescence decay analysis and H NMR titration investigation. Our probe DHAI exhibits linear photoluminescence enhancement from 0 to 500 μM with a detection limit of nanomolar range from non-aqueous to semi-aqueous media. For practical utility, a DHAI-stained test kit employing Whatman-41 filter paper has been fabricated and used as a portable and displayable photonic device for on-site detection of Sarin gas surrogate, DCP. Also, a dip-stick experiment has been demonstrated to identify the vapor of Sarin gas mimics DCP colorimetrically and fluorometrically. The concentrations of DCP in various water samples have been evaluated with the help of a standard fluorescence curve for real sample analysis.
快速准确地识别溶液和蒸气相中有毒的 G 系列神经毒剂对于防止人类遭受不必要的战争和恐怖袭击至关重要，但这在实际操作中极具挑战性。在本文中，我们通过简单的缩合过程设计并合成了一种基于邻苯二甲酰亚胺的灵敏和选择性的比色荧光传感器 DHAI，它对沙林气体模拟物二乙基氯膦（DCP）在液相和气相中分别表现出比率和开启型比色荧光行为。在日光下，由于 DCP 的引入，DHAI 溶液的颜色从黄色变为无色，观察到颜色变化。在 DHAI 溶液中存在 DCP 时，注意到显著的蓝绿色光致发光增强，在便携式 365nm UV 灯下肉眼可见。通过时间分辨光致发光衰减分析和 1 H NMR 滴定研究揭示了 DHAI 检测 DCP 的机制。我们的探针 DHAI 在非水至半水介质中表现出从 0 到 500μM 的线性光致发光增强，检测限为纳摩尔范围。为了实际应用，我们使用 Whatman-41 滤纸制作了一个 DHAI 染色的试剂盒，用作现场检测沙林气体模拟物 DCP 的便携式和可显示的光子器件。此外，还进行了蘸棒实验，以比色和荧光法识别沙林气体模拟物 DCP 的蒸气。借助标准荧光曲线对各种水样中的 DCP 浓度进行了实际样品分析。
