Wang Chan, Luo Jing, Dou Hao, Raise Amir, Ali Mohammed Sardar, Fan Wei, Li Qian
School of Textile Science and Engineering, Key Laboratory of Functional Textile Material and Product of Ministry of Education, Xi'an Polytechnic University, Xi'an, 710048, Shaanxi, China.
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Chemosphere. 2023 Jun;326:138451. doi: 10.1016/j.chemosphere.2023.138451. Epub 2023 Mar 20.
In this research, a new sensor based on graphene/CoO (Gr/CoO) nanocomposite was employed for electrochemically determination of morphine (MOR). The modifier was synthesized with a simple hydrothermal technique and well characterized using X-ray difraction (XRD), scanning electron microscope (SEM) and energy dispersive X-ray spectroscopy (EDS) tools. The modified graphite rod electrode (GRE) was revealed a high electrochemical catalytic activity for the MOR oxidation and employed for the electroanalysis of trace MOR concentration by means of differential pulse voltammetry (DPV) technique. At the optimum experimental factors, the resulting sensor offered a good response for MOR in the concentration range of 0.5-100.0 μM with a detection limit of 80 nM. In addition, the modified electrode demonstrated an acceptable selectivity, stability and reproducibility. This assay was also provided a valid platform for the detection of MOR in environmental and biological samples with acceptable recoveries and RSD in the range of 97.2-102.8% and 1.7-3.4%, respectively. Taking to the simplicity, low cost and short analysis time, this approach is suggested for clinical, environmental and forensic testing of MOR.
在本研究中，一种基于石墨烯/氧化钴（Gr/CoO）纳米复合材料的新型传感器被用于吗啡（MOR）的电化学测定。该修饰剂采用简单的水热技术合成，并使用X射线衍射（XRD）、扫描电子显微镜（SEM）和能量色散X射线光谱（EDS）工具进行了充分表征。修饰后的石墨棒电极（GRE）对MOR氧化表现出高电化学催化活性，并通过差分脉冲伏安法（DPV）技术用于痕量MOR浓度的电分析。在最佳实验条件下，所得传感器对浓度范围为0.5 - 100.0 μM的MOR具有良好响应，检测限为80 nM。此外，修饰电极表现出可接受的选择性、稳定性和重现性。该检测方法还为环境和生物样品中MOR的检测提供了一个有效的平台，回收率在97.2 - 102.8%范围内，相对标准偏差（RSD）在1.7 - 3.4%范围内。鉴于其简单性、低成本和短分析时间，该方法建议用于MOR的临床、环境和法医检测。
