Department of Pharmacology and Toxicology, College of Pharmacy, University of Kerbala, Karbala, Iraq.
Department of Sciences, College of Basic Education, University of Sumer, Rifai, Iraq.
Pan Afr Med J. 2022 Dec 14;43:192. doi: 10.11604/pamj.2022.43.192.36160. eCollection 2022.
Artemisia is one of the important alternative treatments for many diseases, as well as the prevention of the effect of oxidizing substances that cause damage to the various organs of the body, including the liver and kidneys. The kidney and the liver are considered the body's most critical organs, and their functions in storage, metabolism, detoxification and elimination of medications, and their metabolic products make them target structures for "drug-induced" harm. The goal of this investigation was to see if Artemisia extract might protect hepatic and renal tissues from diclofenac-induced damage.
a total of 40 adult Wistar rats were separated equally into four groups randomly. The rats of the control group got only distilled water orally without medicine or therapy, while those in the second group administrated 100mg/kg/day of Artemisia orally for one month. The third group received 10mg/kg/day of Diclofenac (DF) orally. The fourth group received 10mg/kg/day of DF and 100mg/kg day of Artemisia orally. After one month, kidney parameters (albumin, creatinine, and urea) and liver parameters (aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)) were measured.
the results revealed increasing in the kidney (albumin, creatinine, and urea) parameters and liver parameters (AST, ALT, and ALP) in the group treated with diclofenac compared to the control group while they decreased significantly (p≤0.05) in diclofenac + Artemisia group comparing to diclofenac group.
we conclude from these results that Artemisia may have a role in reducing the toxic effect of diclofenac on kidney and liver by decreasing the liver enzymes and kidney criteria in the blood. The aim of the present study is to evaluate the role of Artemisia to reduce the toxic effect of diclofenac on liver and kidney.
青蒿是治疗许多疾病的重要替代疗法之一，也是预防氧化物质对身体各器官（包括肝脏和肾脏）造成损害的有效方法。肾脏和肝脏被认为是人体最重要的器官，它们在储存、代谢、解毒和消除药物及其代谢产物方面的功能使它们成为“药物诱导”伤害的靶结构。本研究的目的是观察青蒿提取物是否能保护肝、肾组织免受双氯芬酸的损伤。
将 40 只成年 Wistar 大鼠随机均分为四组。对照组大鼠仅口服蒸馏水，不给予药物或治疗，第二组大鼠口服 100mg/kg/天的青蒿素，持续一个月。第三组大鼠口服 10mg/kg/天的双氯芬酸（DF）。第四组大鼠口服 10mg/kg/天的 DF 和 100mg/kg/天的青蒿素。一个月后，测定肾脏参数（白蛋白、肌酐和尿素）和肝脏参数（天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）和碱性磷酸酶（ALP））。
结果显示，与对照组相比，双氯芬酸治疗组的肾脏（白蛋白、肌酐和尿素）和肝脏参数（AST、ALT 和 ALP）参数增加，而双氯芬酸+青蒿素组与双氯芬酸组相比，这些参数显著降低（p≤0.05）。
从这些结果中我们得出结论，青蒿素可能通过降低血液中的肝酶和肾脏标准，在降低双氯芬酸对肾脏和肝脏的毒性作用方面发挥作用。本研究的目的是评估青蒿素在降低双氯芬酸对肝脏和肾脏的毒性作用中的作用。
